Toll-like receptor stimulation induces higher TNF-α secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome

Mehdi Yeganeh, Philipp Henneke, Nima Rezaei, Stephan Ehl, Doerte Thiel, Nuria Matamoros, Cristina Pietrogrande, Teresa Espanol, Jiri Litzman, Jose L. Franco, Ozden Sanal, Sara S. Kilic, Anna Breborowicz, Alessandro Plebani, Ellen Renner, Simon Rothenfusser, Thomas R. Hawn, Cristina Woellner, Bodo Grimbacher

Research output: Contribution to journalArticlepeer-review

Abstract

Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with 'cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent features such as progressive skeletal abnormalities. Defective signaling in the Toll-like receptor (TLR) pathways has been suggested as a responsible pathologic mechanism, however, in previous reports, 10 patients revealed no defect in inflammatory cytokine responses to different TLR ligands. Here, we report the increase in pro-inflammatory cytokines TNF-α and IL-8, following TLR2 and TLR4 stimulation in a larger cohort of 25 additional patients with HIES, and provide a meta-analysis of the TLR data in HIES.

Original languageEnglish
Pages (from-to)190-194
Number of pages5
JournalInternational Archives of Allergy and Immunology
Volume146
Issue number3
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Hyper IgE syndrome
  • TNF-α
  • Toll-like receptor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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