Toll-like receptors in chronic lymphocytic leukemia

Marta Muzio, Eleonora Fonte, Federico Caligaris-Cappio

Research output: Contribution to journalArticlepeer-review

Abstract

Toll-like receptors belong to the pattern recognition receptors family present on a variety of immune cells including normal and malignant B-cells. They act as immediate molecular sentinels of innate immunity but also act as a molecular bridge between the innateand the adaptive immune response; distinct Toll-like receptors are able to bind specific pattern molecules of bacteria, viruses and autoantigens. In this review we will briefly introduce the Toll-like receptor family and their expression pattern, signaling and function in the B cell context; following we will summarize the published data on TLR in chronic lymphocytic leukemia, and we will discuss their emerging role in the modulation of leukemia pathobiology.

Original languageEnglish
Article numbere2012055
JournalMediterranean Journal of Hematology and Infectious Diseases
Volume4
Issue number1
DOIs
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Hematology
  • Infectious Diseases

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