Toluene diisocyanate-induced asthma: Clinical findings and bronchial responsiveness studies in 113 exposed subjects with work-related respiratory symptoms

Gianna Moscato, Antonio Dellabianca, Giuseppe Vinci, Stefano M. Candura, Maria Carmen Bossi

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We report the clinical fíndings and the results of inhalation challenge with toluene diisooyanate (TDI) and methacholine in 113 subjects with a history of exposure to TDI and workrelated respiratory symptoms. Only some of the subjects (40.7%) had isooyanate asthma, diagnosed by a positive TDI inhalation challenge. Most reactors had a dual (30.4%) or a late (41.3%) response. The interval between the last occupational exposure and the specifíc challenge was significantly shorter in reactors, and among this group the number of immediate reactions to TDI decreased progressively with an increasing interval. The reactors had a significantly higher proportion of positive responses to methacholine and a significantly lower mean PD15 FEV-1 (provocative dose of methacholine which provoke a 15% decrease in forced expiratory volume in 1 second) (reactors: 557 μg, SEM 92.3; nonreactors: 1346 μg, SEM 128, P <.01). Methacholine challenge could not identify subjects with isocyanate asthma.

Original languageEnglish
Pages (from-to)720-725
Number of pages6
JournalJournal of Occupational Medicine
Issue number6
Publication statusPublished - 1991


ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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