Tomography system to acquire 3D images of cells in laminar flow: Hardware architecture

G. F. Abate; F. Bavaro; G. Castello; P. Daponte; D. Grimaldi; G. Guglielmelli; U. Martinelli; F. Mauro; S. Moisa; M. Napolitano; S. Rapuano; P. Scerbo

doi:10.1109/MEMEA.2006.1644463

Tomography system to acquire 3D images of cells in laminar flow: Hardware architecture

G. F. Abate, F. Bavaro, G. Castello, P. Daponte, D. Grimaldi, G. Guglielmelli, U. Martinelli, F. Mauro, S. Moisa, M. Napolitano, S. Rapuano, P. Scerbo

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The measurement of the frequency of micronuclei induced in cells by genotoxic agent exposure is widely used for analysis of cytogenetic damage. Nevertheless, the conventional microscope analysis does not provide enough sensitivity, and the manual microscope scoring of micronuclei is a tedious and time-consuming procedure. A new flow-cytometry measurement device with specific hardware and software innovations helps in solving such problem. The paper describes the results of a research project aimed to produce a tomography system able to acquire 3D images of cells in laminar flow. This research was supported by the Italian Ministry of Education, University and Research (MIUR) under the project FIRB 2001 RBAUOIZMZ5. On the basis of this research an innovative Image Flow Cytometer has been designed and prototyped. The innovations concern with both the hardware and the software architecture. The paper focuses on the hardware innovations introduced in the standard cyto-fluorimeter architecture to automatically identify and count the cells including micronuclei. The software innovations are described in a successive paper.

Original language	English
Title of host publication	IEEE International Workshop on Medical Measurement and Applications, MeMeA 2006
Pages	68-73
Number of pages	6
Volume	2006
DOIs	https://doi.org/10.1109/MEMEA.2006.1644463
Publication status	Published - 2006
Event	IEEE International Workshop on Medical Measurement and Applications, MeMeA 2006 - Benevento, Italy Duration: Apr 20 2006 → Apr 21 2006

Other

Other	IEEE International Workshop on Medical Measurement and Applications, MeMeA 2006
Country/Territory	Italy
City	Benevento
Period	4/20/06 → 4/21/06

Keywords

Flow cytometer
Laminar flow
Micronucleus

ASJC Scopus subject areas

Engineering(all)

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10.1109/MEMEA.2006.1644463

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Abate, G. F., Bavaro, F., Castello, G., Daponte, P., Grimaldi, D., Guglielmelli, G., Martinelli, U., Mauro, F., Moisa, S., Napolitano, M., Rapuano, S., & Scerbo, P. (2006). Tomography system to acquire 3D images of cells in laminar flow: Hardware architecture. In IEEE International Workshop on Medical Measurement and Applications, MeMeA 2006 (Vol. 2006, pp. 68-73). [1644463] https://doi.org/10.1109/MEMEA.2006.1644463

Abate, GF, Bavaro, F, Castello, G, Daponte, P, Grimaldi, D, Guglielmelli, G, Martinelli, U, Mauro, F, Moisa, S, Napolitano, M, Rapuano, S & Scerbo, P 2006, Tomography system to acquire 3D images of cells in laminar flow: Hardware architecture. in IEEE International Workshop on Medical Measurement and Applications, MeMeA 2006. vol. 2006, 1644463, pp. 68-73, IEEE International Workshop on Medical Measurement and Applications, MeMeA 2006, Benevento, Italy, 4/20/06. https://doi.org/10.1109/MEMEA.2006.1644463

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AB - The measurement of the frequency of micronuclei induced in cells by genotoxic agent exposure is widely used for analysis of cytogenetic damage. Nevertheless, the conventional microscope analysis does not provide enough sensitivity, and the manual microscope scoring of micronuclei is a tedious and time-consuming procedure. A new flow-cytometry measurement device with specific hardware and software innovations helps in solving such problem. The paper describes the results of a research project aimed to produce a tomography system able to acquire 3D images of cells in laminar flow. This research was supported by the Italian Ministry of Education, University and Research (MIUR) under the project FIRB 2001 RBAUOIZMZ5. On the basis of this research an innovative Image Flow Cytometer has been designed and prototyped. The innovations concern with both the hardware and the software architecture. The paper focuses on the hardware innovations introduced in the standard cyto-fluorimeter architecture to automatically identify and count the cells including micronuclei. The software innovations are described in a successive paper.

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Tomography system to acquire 3D images of cells in laminar flow: Hardware architecture

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