Tomography system to acquire 3D images of cells in laminar flow: Software architecture

G. F. Abate; F. Bavaro; G. Castello; P. Daponte; D. Grimaldi; G. Guglielmelli; U. Martinelli; F. Mauro; S. Moisa; M. Napolitano; S. Rapuano; P. Scerbo

doi:10.1109/MEMEA.2006.1644464

Tomography system to acquire 3D images of cells in laminar flow: Software architecture

G. F. Abate, F. Bavaro, G. Castello, P. Daponte, D. Grimaldi, G. Guglielmelli, U. Martinelli, F. Mauro, S. Moisa, M. Napolitano, S. Rapuano, P. Scerbo

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In the framework of the project FIRB 2001 the Italian Ministry of Education, University and Research (MIUR) has supported the research project RSAUOIZMZ5 aimed to produce a tomography system able to acquire 3D images of cells in laminar flow. The innovative aspects of the new Image Flow Cytometer (IFC) designed and prototyped under this project regard to both the hardware and the software architecture. In particular, it is able to automatically identify micronuclei on the acquired images of flowing lymphocytes. Therefore, the new IFC overcomes the characteristics of the conventional ones The paper focuses on the software innovations regarding to (i) the digital signal processing procedure, (ii) the optimized methodology for classifying the different cell types, (iii) the programmable gain of each input channel, and (iv) the image preprocessing to detect the micronucleus in the acquired image of the human lymphocytes. In order to highlight the improved performance of the IFC software architecture, results of preliminary experimental tests are shown.

Original language	English
Title of host publication	IEEE International Workshop on Medical Measurement and Applications, MeMeA 2006
Pages	74-79
Number of pages	6
Volume	2006
DOIs	https://doi.org/10.1109/MEMEA.2006.1644464
Publication status	Published - 2006
Event	IEEE International Workshop on Medical Measurement and Applications, MeMeA 2006 - Benevento, Italy Duration: Apr 20 2006 → Apr 21 2006

Other

Other	IEEE International Workshop on Medical Measurement and Applications, MeMeA 2006
Country	Italy
City	Benevento
Period	4/20/06 → 4/21/06

Keywords

Flow cytometer
Image detection
Micronucleus

ASJC Scopus subject areas

Engineering(all)

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Abate, G. F., Bavaro, F., Castello, G., Daponte, P., Grimaldi, D., Guglielmelli, G., Martinelli, U., Mauro, F., Moisa, S., Napolitano, M., Rapuano, S., & Scerbo, P. (2006). Tomography system to acquire 3D images of cells in laminar flow: Software architecture. In IEEE International Workshop on Medical Measurement and Applications, MeMeA 2006 (Vol. 2006, pp. 74-79). [1644464] https://doi.org/10.1109/MEMEA.2006.1644464

Tomography system to acquire 3D images of cells in laminar flow : Software architecture. / Abate, G. F.; Bavaro, F.; Castello, G.; Daponte, P.; Grimaldi, D.; Guglielmelli, G.; Martinelli, U.; Mauro, F.; Moisa, S.; Napolitano, M.; Rapuano, S.; Scerbo, P.

IEEE International Workshop on Medical Measurement and Applications, MeMeA 2006. Vol. 2006 2006. p. 74-79 1644464.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abate, GF, Bavaro, F, Castello, G, Daponte, P, Grimaldi, D, Guglielmelli, G, Martinelli, U, Mauro, F, Moisa, S, Napolitano, M, Rapuano, S & Scerbo, P 2006, Tomography system to acquire 3D images of cells in laminar flow: Software architecture. in IEEE International Workshop on Medical Measurement and Applications, MeMeA 2006. vol. 2006, 1644464, pp. 74-79, IEEE International Workshop on Medical Measurement and Applications, MeMeA 2006, Benevento, Italy, 4/20/06. https://doi.org/10.1109/MEMEA.2006.1644464

Abate, G. F. ; Bavaro, F. ; Castello, G. ; Daponte, P. ; Grimaldi, D. ; Guglielmelli, G. ; Martinelli, U. ; Mauro, F. ; Moisa, S. ; Napolitano, M. ; Rapuano, S. ; Scerbo, P. / Tomography system to acquire 3D images of cells in laminar flow : Software architecture. IEEE International Workshop on Medical Measurement and Applications, MeMeA 2006. Vol. 2006 2006. pp. 74-79

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AB - In the framework of the project FIRB 2001 the Italian Ministry of Education, University and Research (MIUR) has supported the research project RSAUOIZMZ5 aimed to produce a tomography system able to acquire 3D images of cells in laminar flow. The innovative aspects of the new Image Flow Cytometer (IFC) designed and prototyped under this project regard to both the hardware and the software architecture. In particular, it is able to automatically identify micronuclei on the acquired images of flowing lymphocytes. Therefore, the new IFC overcomes the characteristics of the conventional ones The paper focuses on the software innovations regarding to (i) the digital signal processing procedure, (ii) the optimized methodology for classifying the different cell types, (iii) the programmable gain of each input channel, and (iv) the image preprocessing to detect the micronucleus in the acquired image of the human lymphocytes. In order to highlight the improved performance of the IFC software architecture, results of preliminary experimental tests are shown.

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