Tongue tremor in neurofascin-155 IgG4 seropositive chronic inflammatory polyradiculoneuropathy

Chiara Briani, Alessandro Salvalaggio, Marta Ruiz, Mario Cacciavillani, Francesca Rinaldi, Ilaria Callegari, Roberto Gasparotti, Diego Franciotta

Research output: Contribution to journalArticlepeer-review


Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) with anti-neurofascin-155 antibodies is a subgroup of CIDP with tremor and poor response to intravenous immunoglobulins. A 23-year-old male presented with a 6-month history ataxic-stepping gait, stocking tactile hypoesthesia, areflexia, tremor at limbs and tongue. Neurophysiology and cerebrospinal fluid analysis supported the diagnosis of CIDP. Tongue EMG was negative. Serum was positive for neurofascin-155 IgG4. His symptoms improved with intravenous methylprednisolone and then immunoglobulins, but not the tremor. Neurofascin-155 antibodies binding to cerebellar neurons suggests its central origin. This is the first neurofascin-155 antibody-seropositive patient with also tongue tremor, who is candidate to rituximab.

Original languageEnglish
Pages (from-to)178-180
Number of pages3
JournalJournal of Neuroimmunology
Publication statusPublished - Jan 29 2019


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