Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice

A. Balsari, C. Rumio, D. Morelli, L. Sfondrini, E. Nardini, I. Barajon, S. Ménard

Research output: Contribution to journalArticle

Abstract

One of the most severe side effects of anti-tumour chemotherapy is mucositis due to drug toxicity for rapidly dividing cells. We show here that anti-DXR monoclonal antibodies can prevent DXR-induced damage. Indeed, apoptosis, confined to the proliferative compartment of the basal mucosa, observed in the tongue of DXR-treated mice was completely inhibited by topical application of the anti-DXR antibodies.

Original languageEnglish
Pages (from-to)1964-1967
Number of pages4
JournalBritish Journal of Cancer
Volume85
Issue number12
Publication statusPublished - 2001

Keywords

  • Antidotal activity
  • Apoptosis
  • Doxorubicin
  • Monoclonal antibody
  • Mucositis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice'. Together they form a unique fingerprint.

  • Cite this