Topical administration of hyaluronic acid in children with recurrent or chronic middle ear inflammations

Sara Torretta, Paola Giovanna Marchisio, Vittorio Rinaldi, Michele Gaffuri, Carla Pascariello, Lorenzo Drago, Elena Baggi, Lorenzo Pignataro

Research output: Contribution to journalArticle

Abstract

Hyaluronic acid (HA) treatment has been successfully performed in patients with recurrent upper airway infections or rhinitis. The aim of this study was to assess the efficacy and safety of the topical nasal administration of an HA-based compound by investigating its effects in children with recurrent or chronic middle ear inflammations and chronic adenoiditis. A prospective, single-blind, 1:1 randomised controlled study was performed to compare otoscopy, tympanometry and pure-tone audiometry in children which received the daily topical administration of normal 0.9% sodium chloride saline solution (control group) or 9 mg of sodium hyaluronate in 3 mL of a 0.9% sodium saline solution. The final analysis was based on 116 children (49.1% boys; mean age, 62.9 ± 17.9 months): 58 in the control group and 58 in the study group. At the end of follow-up, the prevalence of patients with impaired otoscopy was significantly lower in the study group (P value = 0.024) compared to baseline but not in the control group. In comparison with baseline, the prevalence of patients with impaired tympanometry at the end of the follow-up period was significantly lower in the study group (P value = 0.047) but not in the control group. The reduction in the prevalence of patients with conductive hearing loss (CHL) (P value = 0.008) and those with moderate CHL (P value = 0.048) was significant in the study group, but not in the control group. The mean auditory threshold had also significantly improved by the end of treatment in the study group (P value = 0.004) but not in the control group. Our findings confirm the safety of intermittent treatment with a topical nasal sodium hyaluronate solution and are the first to document its beneficial effect on clinical and audiological outcomes in children with recurrent or chronic middle ear inflammations associated with chronic adenoiditis.

Original languageEnglish
Pages (from-to)438-442
Number of pages5
JournalInternational Journal of Immunopathology and Pharmacology
Volume29
Issue number3
DOIs
Publication statusPublished - Sep 1 2016

Keywords

  • adenoids
  • children
  • otitis

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy

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