Topical and oral ketorolac administration increases the intraocular pressure-lowering effect of latanoprost

Ciro Costagliola, Claudio Campa, Paolo Perri, Francesco Parmeggiani, Mario R. Romano, Carlo Incorvaia

Research output: Contribution to journalArticle

Abstract

Purpose: To verify the influence of a non-steroidal anti-inflammatory drug (NSAID), ketorolac (topical and oral) on the intraocular pressure reduction induced by 0.005% latanoprost topical administration, both in patients affected by primary open-angle glaucoma and in healthy controls. Methods: Two groups of subjects were enrolled for this randomized, prospective, masked clinical study: 16 glaucomatous patients well controlled with 0.005% latanoprost eyedrops (group I) and 16 healthy adult volunteers (group II). Group I subjects were treated at one-week intervals with 10 mg of oral ketorolac, oral placebo, topical ketorolac, and topical placebo, respectively; for each administration modality, the switch between drug and placebo was performed in a randomized, crossover, double-blind fashion. Group II subjects followed the same protocol, with the topical once-daily 0.005% latanoprost treatment starting three days prior to the ketorolac/placebo administration. Intraocular pressure (IOP) was investigated in both groups on the day of oral/topical administration of ketorolac or placebo at baseline (8:00 AM) and at the following intervals: 1, 2, 4, 8, 12, and 24 hours. Results: No significant IOP changes after oral and topical placebo administration were observed in either group. In contrast, when the subjects received ketorolac (either oral or topical), a marked decrease in IOP was recorded, with a noticeable fall at the first hour after the NSAID administration (p = 0.01), which remained still significant 8 hours later (p <0.05). Conclusion: Topical and oral ketorolac strengthens the latanoprost-induced IOP-lowering effect both in glaucomatous patients and in healthy subjects.

Original languageEnglish
Pages (from-to)477-482
Number of pages6
JournalCurrent Eye Research
Volume33
Issue number5-6
DOIs
Publication statusPublished - May 2008

Keywords

  • Intraocular pressure
  • Ketorolac
  • Non-steroidal anti-inflammatory drugs

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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    Costagliola, C., Campa, C., Perri, P., Parmeggiani, F., Romano, M. R., & Incorvaia, C. (2008). Topical and oral ketorolac administration increases the intraocular pressure-lowering effect of latanoprost. Current Eye Research, 33(5-6), 477-482. https://doi.org/10.1080/02713680802100845