Topical application of 1,25-dihydroxyvitamin D3 (calcitriol) is an effective and reliable therapy to cure skin lesions in psoriatic children

G. Saggese, G. Federico, R. Battini

Research output: Contribution to journalArticlepeer-review

Abstract

We studied, in vivo, the effects of a calcitriol-containing ointment (3 μg of calcitriol per gram of petrolatum) topically applied on skin lesions in children affected by psoriasis vulgaris. Each patient was instructed to apply the ointment, about 1 g once a day at bedtime followed by occlusive dressing with plastic wrap, on one-side lesion (treated) and petrolatum alone on the equivalent controlateral site (placebo) (total weekly dose of calcitriol: approixmately 21 μg/patient). After 4 weeks of topical treatment all children showed a complete clearing of their skin lesions on the treated side, without appreciable changes on the placebo side. Serum ionised calcium, calcium and calcitriol levels or urinary calcium excretion did not vary significantly throughout the period of therapy. These findings suggest that topical calcitriol may be an effective and safe alternative therapy for psoriasis in children.

Original languageEnglish
Pages (from-to)389-392
Number of pages4
JournalEuropean Journal of Pediatrics
Volume152
Issue number5
DOIs
Publication statusPublished - May 1993

Keywords

  • 1,25-Dihydroxyvitamin D
  • Psoriasis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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