Topical azithromycin as a novel treatment for ocular rosacea

Flavio Mantelli, Antonio Di Zazzo, Marta Sacchetti, Caterina Dianzani, Alessandro Lambiase, Stefano Bonini

Research output: Contribution to journalArticlepeer-review


Purpose: Acne rosacea is a common dermatological conditions associated with blepharitis. Current treatments include artificial tears, lid hygiene, and systemic doxycycline. In this study the authors evaluate the effectiveness of topical azithromycin in ocular rosacea. Methods: The authors enrolled 37 ocular rosacea patients: 12 were treated with systemic doxycycline, 16 with azithromycin eyedrops, and 9 did not receive medical treatments. Ocular signs and symptoms and side effects were evaluated at baseline and at 1-month follow-up. Results: A significant improvement in TF-BUT, meibomian gland plugging, and Oxford score associated with symptom reduction was reported by all patients after 1 month. All treatments were well tolerated, with mild gastro-intestinal symptoms in 33% of the doxycycline group and mild burning after instillation in the azithromycin group. Conclusions: Topical azithromycin may represent an additional treatment for ocular rosacea, with a shorter duration of treatment and absence of gastrointestinal side effects as compared to systemic doxycycline.

Original languageEnglish
Pages (from-to)371-377
Number of pages7
JournalOcular Immunology and Inflammation
Issue number5
Publication statusPublished - Oct 2013


  • Acne rosacea
  • Azithromycin
  • Blepharitis
  • Doxycycline
  • Meibomian glands

ASJC Scopus subject areas

  • Ophthalmology
  • Immunology and Allergy


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