Topical clindamycin 1% vs. linoleic acid-rich phosphatidylcholine and nicotinamide 4% in the treatment of acne: A multicentre-randomized trial

P. Morganti, E. Berardesca, B. Guarneri, F. Guarneri, G. Fabrizi, P. Palombo, M. Palombo

Research output: Contribution to journalArticle

Abstract

Synopsis It has been shown that topical linoleic acid rich- phosphatidylcholine seems to be effective in normalization of follicular hyperkeratinization, whereas nicotinamide has an interesting anti-inflammatory effect. However, little is known about their combined effect on acne. A multicentre, double-blind, 12-week randomized vehicle and parallel-active control study was conducted by clinical and biophysical non-invasive measurements to evaluate the efficacy, tolerability and safety of a 4% nicotinamide-phospholipidic (N-PHCL) emulsion vs. 1% topical clindamycin phosphate applied once daily. Four percentage N-PHCL cosmetic treatment resulted slightly superior to topical clindamycin with all the parameters studied for its better compliance and the global clinical improvement. ICS

Original languageEnglish
Pages (from-to)467-476
Number of pages10
JournalInternational Journal of Cosmetic Science
Volume33
Issue number5
DOIs
Publication statusPublished - Oct 2011

Keywords

  • acne
  • clindamicin
  • linoleic acid
  • nicotinamide
  • phosphatidylcholine

ASJC Scopus subject areas

  • Dermatology
  • Colloid and Surface Chemistry
  • Ageing
  • Drug Discovery
  • Pharmaceutical Science
  • Chemistry (miscellaneous)

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