Topical clindamycin 1% vs. linoleic acid-rich phosphatidylcholine and nicotinamide 4% in the treatment of acne

A multicentre-randomized trial

P. Morganti, E. Berardesca, B. Guarneri, F. Guarneri, G. Fabrizi, P. Palombo, M. Palombo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Synopsis It has been shown that topical linoleic acid rich- phosphatidylcholine seems to be effective in normalization of follicular hyperkeratinization, whereas nicotinamide has an interesting anti-inflammatory effect. However, little is known about their combined effect on acne. A multicentre, double-blind, 12-week randomized vehicle and parallel-active control study was conducted by clinical and biophysical non-invasive measurements to evaluate the efficacy, tolerability and safety of a 4% nicotinamide-phospholipidic (N-PHCL) emulsion vs. 1% topical clindamycin phosphate applied once daily. Four percentage N-PHCL cosmetic treatment resulted slightly superior to topical clindamycin with all the parameters studied for its better compliance and the global clinical improvement. ICS

Original languageEnglish
Pages (from-to)467-476
Number of pages10
JournalInternational Journal of Cosmetic Science
Volume33
Issue number5
DOIs
Publication statusPublished - Oct 2011

Fingerprint

Linoleic acid
Niacinamide
Clindamycin
Acne Vulgaris
Linoleic Acid
Phosphatidylcholines
Multicenter Studies
Emulsions
Phosphates
Cosmetics
Compliance
Anti-Inflammatory Agents
Safety
clindamycin phosphate

Keywords

  • acne
  • clindamicin
  • linoleic acid
  • nicotinamide
  • phosphatidylcholine

ASJC Scopus subject areas

  • Dermatology
  • Colloid and Surface Chemistry
  • Ageing
  • Drug Discovery
  • Pharmaceutical Science
  • Chemistry (miscellaneous)

Cite this

Topical clindamycin 1% vs. linoleic acid-rich phosphatidylcholine and nicotinamide 4% in the treatment of acne : A multicentre-randomized trial. / Morganti, P.; Berardesca, E.; Guarneri, B.; Guarneri, F.; Fabrizi, G.; Palombo, P.; Palombo, M.

In: International Journal of Cosmetic Science, Vol. 33, No. 5, 10.2011, p. 467-476.

Research output: Contribution to journalArticle

Morganti, P. ; Berardesca, E. ; Guarneri, B. ; Guarneri, F. ; Fabrizi, G. ; Palombo, P. ; Palombo, M. / Topical clindamycin 1% vs. linoleic acid-rich phosphatidylcholine and nicotinamide 4% in the treatment of acne : A multicentre-randomized trial. In: International Journal of Cosmetic Science. 2011 ; Vol. 33, No. 5. pp. 467-476.
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