TRATTAMENTO DELLA DERMATITE IRRITATIVA MEDIANTE STEROIDI TOPICI: MONO- O BISOMMINISTRAZIONE?

Translated title of the contribution: Topical corticosteroids in the treatment of irritant dermatitis: s.i.d. or b.i.d.?

E. Berardesca, F. Distante, G. P. Vignoli, G. Rabbiosi

Research output: Contribution to journalArticlepeer-review

Abstract

Topical corticosteroids b.i.d. are commonly used in the treatment of contact dermatitis. This study evaluates the efficacy of a new corticosteroid molecule designed for s.i.d. use. 9 healthy subjects entered the study on the volar foream, a random selection of 4 areas, 4 cm 2 each was made. One site served as control. Irritation was induced by occlusive application of 5% sodium lauryl sulphate in water on the other 3 sites. The irritated sites were treated for 4 days respectively with: 0.025% budesonide in cream (b.i.d.), methylprednisolone aceponate 0.1% in cream (s.i.d.) and base cream (s.i.d.). Recovery of irritation was monitored by transepidermal water loss (TEWL) measurements. The results show significant differences between the treatments at the 3rd (p <0.03) and 4th (p <0.05) day. The data show a marked reduction in TEWL values in the site treated with the molecule designed for a once a day application. In conclusion, the study demonstrates that methylprednisolone aceponate 0.1% is effective in treating skin irritation. The use of these corticosteroids may increase the patient's compliance and reduce the risk of side effects.

Translated title of the contributionTopical corticosteroids in the treatment of irritant dermatitis: s.i.d. or b.i.d.?
Original languageItalian
JournalGiornale Italiano di Dermatologia e Venereologia
Volume129
Issue number4
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Dermatology

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