Topical estrogen therapy and lower urinary tract in postmenopausal women

S. Salvatore, M. Soligo, M. Fasola, A. Tusei, P. Pellegrini, A. Pozzi, P. F. Bolis

Research output: Contribution to journalArticlepeer-review


Objective: Menopause brings about reduced estrogen levels. This leads to increased prevalence of urinary symptoms such as dysuria, frequency, nocturia, urgency and urinary incontinence. This study investigated the efficacy of vaginal promestriene in menopausal women with urinary tract dysfunction. Method: Forty-four menopausal women with urinary symptoms were enrolled after collecting a detailed history (analogue imaging), assessing quality of life (SF-36) and testing urodynamics. Promestriene vaginal cream was prescribed at a dose of 1 g/die for 15 days followed by 1 g twice a week. Improvement in general health conditions was assessed and documented by quality-of-life questionnaires. Results: Forty-one out of 44 patients were evaluated at 12 months. Improvement in urinary symptoms such as frequency, stress and urge incontinence was observed with no significant urodynamic changes. Conclusion: In this study, topical promestriene used for one year improved urinary symptoms and quality of life with no significant changes in urodynamic parameters.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalItalian Journal of Gynaecology and Obstetrics
Issue number3
Publication statusPublished - 1998


  • Estrogen therapy
  • Menopause
  • Urinary symptoms

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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