Topical nerve growth factor as a visual rescue strategy in pediatric optic gliomas: A pilot study including electrophysiology

Benedetto Falsini, Antonio Chiaretti, Giuseppe Barone, Marco Piccardi, Filomena Pierri, Cesare Colosimo, Ilaria Lazzareschi, Antonio Ruggiero, Vincenzo Parisi, Antonello Fadda, Emilio Balestrazzi, Riccardo Riccardi

Research output: Contribution to journalArticle

Abstract

Background. To date, no specific therapy is available for optic glioma (OG)-induced visual loss. Objective. To evaluate the effects on visual function of murine nerve growth factor (NGF) eye drop administration in children with severe visual impairment due to low-grade OGs. Methods. Five patients with OGs and advanced optic nerve atrophy were assessed before and after a single 10-day course of 1 mg murine NGF topical administration by clinical evaluation, visual evoked potentials (VEPs), and brain magnetic resonance imaging (MRI). VEPs, the main functional outcome measure, were recorded at baseline and 1, 30, 45, 90, and 180 days posttreatment. MRI examinations were performed at baseline and at 180 days after NGF treatment. Six untreated control patients with OGs also underwent serial VEPs, clinical testing, and MRI assessments. Results. After NGF treatment, median VEPs amplitude showed a progressive increase from the baseline values (P

Original languageEnglish
Pages (from-to)512-520
Number of pages9
JournalNeurorehabilitation and Neural Repair
Volume25
Issue number6
DOIs
Publication statusPublished - Jul 2011

Keywords

  • nerve growth factor
  • optic gliomas
  • retinal ganglion cells
  • visual evoked potentials
  • visual function rescue

ASJC Scopus subject areas

  • Clinical Neurology
  • Rehabilitation
  • Neurology

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  • Cite this

    Falsini, B., Chiaretti, A., Barone, G., Piccardi, M., Pierri, F., Colosimo, C., Lazzareschi, I., Ruggiero, A., Parisi, V., Fadda, A., Balestrazzi, E., & Riccardi, R. (2011). Topical nerve growth factor as a visual rescue strategy in pediatric optic gliomas: A pilot study including electrophysiology. Neurorehabilitation and Neural Repair, 25(6), 512-520. https://doi.org/10.1177/1545968310397201