Topical Prilocaine-Lidocaine Cream Combined with Peripheral Nerve Block Improves Pain Control in Prostatic Biopsy: Results from a Prospective Randomized Trial

Marco Raber, Vincenzo Scattoni, Marco Roscigno, Federico Dehò, Alberto Briganti, Andrea Salonia, Andrea Gallina, Valerio Di Girolamo, Francesco Montorsi, Patrizio Rigatti

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To compare pain control results between periprostatic nerve block alone and combined with topical prilocaine-lidocaine cream as local anesthesia of prostate biopsy. Methods: Three hundred patients were randomized to receive PNB (group 1), topical anesthesia of the anal ring, anal canal, and anterior rectal wall combined with PNB (group 2) and placebo (group 3). Patients were asked to use scale of 0-10 to complete a visual analogue scale questionnaire about pain during probe insertion (VAS1), periprostatic infiltration (VAS2), and cores (VAS3). Results: Pain during probe insertion in group 2 was significantly less than in groups 1 and 3 (VAS1, 0.29 vs. 1.46 and 1.48; p <0.0001). Pain during periprostatic infiltration was also reduced in group 2 compared with group 1 (VAS2, 1.06 vs. 2.39; p <0.0001). Pain control was similar during biopsy in the PNB and combined groups (VAS3, 0.43 vs. 0.37; p = 0.77) and was superior to group 3 (VAS3, 3.02; p <0.0001). In younger patients (cut off, median age 67 yr) these differences were still significant between groups 1 and 2 (VAS1, 1.95 vs.0.31; p <0.0001 and VAS2, 2.97 vs. 1,15; p <0.0001), but not in older patients (VAS1, 0.91 vs. 0.28; p = 0.06; VAS2, 1.52 vs. 0,92; p = 0.06). Vagal symptoms were registered in 36 (12%) patients in all groups. Sepsis occurred in one group 1 patient and in one group 2 patient. Rectal bleeding was observed in one group 2 patient. Conclusion: Combined prilocaine-lidocaine cream topically placed with PNB is superior to PNB alone and may be of maximum benefit for younger patients.

Original languageEnglish
Pages (from-to)967-975
Number of pages9
JournalEuropean Urology
Volume53
Issue number5
DOIs
Publication statusPublished - May 2008

Keywords

  • Anesthesia
  • Biopsy
  • Prostate cancer

ASJC Scopus subject areas

  • Urology

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