Abstract
We investigated the efficacy of dexamethasone plus diclofenac eye drops as prophylaxis for conjunctivitis induced by high-dose (HD) cytarabine (Ara-C). Sixty patients were randomized to receive either dexamethasone (group A, n=29) or dexamethasone plus diclofenac (group B, n=31). Conjunctivitis was experienced by 13/29 (45%) patients in group A, and 4/31 (13%) patients in group B (p≤0.009). Twelve out of 13 patients in group A who developed ocular toxicity had grade 2-3 conjunctivitis whereas only one of four patients affected in group B experienced a similar grade of conjunctivitis. The incidence and severity of HD Ara-C-induced conjunctivitis are significantly reduced by combined dexamethasone/diclofenac prophylaxis.
Original language | English |
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Pages (from-to) | 255-257 |
Number of pages | 3 |
Journal | Haematologica |
Volume | 91 |
Issue number | 2 |
Publication status | Published - Feb 2006 |
Keywords
- Conjunctivitis
- Cytosine arabinoside
- Prophylaxis
ASJC Scopus subject areas
- Hematology