Topical prophylaxis of conjunctivitis induced by high-dose cytosine arabinoside

Paola Matteucci, Carmelo Carlo-Stella, Massimo Di Nicola, Michele Magni, Anna Guidetti, Maddalena Marchesi, Alessandro Massimo Gianni

Research output: Contribution to journalArticlepeer-review


We investigated the efficacy of dexamethasone plus diclofenac eye drops as prophylaxis for conjunctivitis induced by high-dose (HD) cytarabine (Ara-C). Sixty patients were randomized to receive either dexamethasone (group A, n=29) or dexamethasone plus diclofenac (group B, n=31). Conjunctivitis was experienced by 13/29 (45%) patients in group A, and 4/31 (13%) patients in group B (p≤0.009). Twelve out of 13 patients in group A who developed ocular toxicity had grade 2-3 conjunctivitis whereas only one of four patients affected in group B experienced a similar grade of conjunctivitis. The incidence and severity of HD Ara-C-induced conjunctivitis are significantly reduced by combined dexamethasone/diclofenac prophylaxis.

Original languageEnglish
Pages (from-to)255-257
Number of pages3
Issue number2
Publication statusPublished - Feb 2006


  • Conjunctivitis
  • Cytosine arabinoside
  • Prophylaxis

ASJC Scopus subject areas

  • Hematology


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