Topical prophylaxis of conjunctivitis induced by high-dose cytosine arabinoside

Paola Matteucci; Carmelo Carlo-Stella; Massimo Di Nicola; Michele Magni; Anna Guidetti; Maddalena Marchesi; Alessandro Massimo Gianni

Topical prophylaxis of conjunctivitis induced by high-dose cytosine arabinoside

Paola Matteucci, Carmelo Carlo-Stella, Massimo Di Nicola, Michele Magni, Anna Guidetti, Maddalena Marchesi, Alessandro Massimo Gianni

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the efficacy of dexamethasone plus diclofenac eye drops as prophylaxis for conjunctivitis induced by high-dose (HD) cytarabine (Ara-C). Sixty patients were randomized to receive either dexamethasone (group A, n=29) or dexamethasone plus diclofenac (group B, n=31). Conjunctivitis was experienced by 13/29 (45%) patients in group A, and 4/31 (13%) patients in group B (p≤0.009). Twelve out of 13 patients in group A who developed ocular toxicity had grade 2-3 conjunctivitis whereas only one of four patients affected in group B experienced a similar grade of conjunctivitis. The incidence and severity of HD Ara-C-induced conjunctivitis are significantly reduced by combined dexamethasone/diclofenac prophylaxis.

Original language	English
Pages (from-to)	255-257
Number of pages	3
Journal	Haematologica
Volume	91
Issue number	2
Publication status	Published - Feb 2006

Keywords

Conjunctivitis
Cytosine arabinoside
Prophylaxis

ASJC Scopus subject areas

Hematology

Cite this

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abstract = "We investigated the efficacy of dexamethasone plus diclofenac eye drops as prophylaxis for conjunctivitis induced by high-dose (HD) cytarabine (Ara-C). Sixty patients were randomized to receive either dexamethasone (group A, n=29) or dexamethasone plus diclofenac (group B, n=31). Conjunctivitis was experienced by 13/29 (45%) patients in group A, and 4/31 (13%) patients in group B (p≤0.009). Twelve out of 13 patients in group A who developed ocular toxicity had grade 2-3 conjunctivitis whereas only one of four patients affected in group B experienced a similar grade of conjunctivitis. The incidence and severity of HD Ara-C-induced conjunctivitis are significantly reduced by combined dexamethasone/diclofenac prophylaxis.",

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AU - Matteucci, Paola

AU - Carlo-Stella, Carmelo

AU - Di Nicola, Massimo

AU - Magni, Michele

AU - Guidetti, Anna

AU - Marchesi, Maddalena

AU - Gianni, Alessandro Massimo

PY - 2006/2

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AB - We investigated the efficacy of dexamethasone plus diclofenac eye drops as prophylaxis for conjunctivitis induced by high-dose (HD) cytarabine (Ara-C). Sixty patients were randomized to receive either dexamethasone (group A, n=29) or dexamethasone plus diclofenac (group B, n=31). Conjunctivitis was experienced by 13/29 (45%) patients in group A, and 4/31 (13%) patients in group B (p≤0.009). Twelve out of 13 patients in group A who developed ocular toxicity had grade 2-3 conjunctivitis whereas only one of four patients affected in group B experienced a similar grade of conjunctivitis. The incidence and severity of HD Ara-C-induced conjunctivitis are significantly reduced by combined dexamethasone/diclofenac prophylaxis.

KW - Conjunctivitis

KW - Cytosine arabinoside

KW - Prophylaxis

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Topical prophylaxis of conjunctivitis induced by high-dose cytosine arabinoside

Abstract

Keywords

ASJC Scopus subject areas

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