Topical prostaglandin E2 and chemo- and radio-induced oral mucositis: Report on 15 cases

Research output: Contribution to journalArticle

Abstract

Oral mucositis is a frequent complication of specific antineoplastic treatments. Mouth lesions have a great impact on the quality of life of cancer patients. Current topical and systemic therapies have not yet achieved completely satisfactory results. We studied the effect of topical use of prostaglandin E2 (PGE2) 2.25 mg/day on oral mucositis of 15 chemo- or radio-treated cancer patients. Absolute mean VAS value on mouth pain decreased from 71.2 at T0, to 34.1 at T3 (p <0.001) and to 14.1 at T6 (p <0.001). Objective evaluation according to Miller scale showed significant improvement at day 3 and 6, as well. We suggest that PGE2 could be a useful additional therapeutic agent to palliate oral symptoms.

Original languageEnglish
Pages (from-to)205-208
Number of pages4
JournalOncology Reports
Volume3
Issue number1
Publication statusPublished - 1996

Keywords

  • mouth care
  • oral mucositis
  • prostaglandins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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