Topical testosterone in the treatment of vulvar lichen sclerosus

M. Sideri, M. Origoni, L. Spinaci, A. Ferrari

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Objectives: Comparison between 2% testosterone propionate and petrolatum ointment in the treatment of vulvar lichen sclerosus in a randomized, double-blind, controlled clinical study. Methods: Fifty-eight consecutive patients with histologically confirmed vulvar lichen sclerosus were enrolled. They underwent a 1-year period of topical treatment with either medication, with clinical evaluations of symptoms and gross appearance at 2-month intervals, followed by histological evaluation at the end of the treatment period. Statistical analysis was performed according to the chisquared test and the Student-Newman-Keuls test. Results: A substantial improvement in symptoms was achieved in 20 (66.6%) patients in the testosterone group and in 21 (75%) patients in the placebo group. No statistical differences were observed between the two groups. Gross changes were observed in a few cases and no case demonstrated histologic modifications. Conclusions: Petrolatum ointment is as effective as 2% testosterone in the treatment of vulvar lichen sclerosus.

Original languageEnglish
Pages (from-to)53-56
Number of pages4
JournalInternational Journal of Gynecology and Obstetrics
Volume46
Issue number1
DOIs
Publication statusPublished - 1994

Fingerprint

Vulvar Lichen Sclerosus
Testosterone
Petrolatum
Ointments
Testosterone Propionate
Symptom Assessment
Therapeutics
Placebos
Students

Keywords

  • Lichen sclerosus
  • Testosterone
  • Topical treatment
  • Vulva
  • Vulvar dystrophy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Topical testosterone in the treatment of vulvar lichen sclerosus. / Sideri, M.; Origoni, M.; Spinaci, L.; Ferrari, A.

In: International Journal of Gynecology and Obstetrics, Vol. 46, No. 1, 1994, p. 53-56.

Research output: Contribution to journalArticle

Sideri, M. ; Origoni, M. ; Spinaci, L. ; Ferrari, A. / Topical testosterone in the treatment of vulvar lichen sclerosus. In: International Journal of Gynecology and Obstetrics. 1994 ; Vol. 46, No. 1. pp. 53-56.
@article{236b28ce9d064d1683756ea672ed6eda,
title = "Topical testosterone in the treatment of vulvar lichen sclerosus",
abstract = "Objectives: Comparison between 2{\%} testosterone propionate and petrolatum ointment in the treatment of vulvar lichen sclerosus in a randomized, double-blind, controlled clinical study. Methods: Fifty-eight consecutive patients with histologically confirmed vulvar lichen sclerosus were enrolled. They underwent a 1-year period of topical treatment with either medication, with clinical evaluations of symptoms and gross appearance at 2-month intervals, followed by histological evaluation at the end of the treatment period. Statistical analysis was performed according to the chisquared test and the Student-Newman-Keuls test. Results: A substantial improvement in symptoms was achieved in 20 (66.6{\%}) patients in the testosterone group and in 21 (75{\%}) patients in the placebo group. No statistical differences were observed between the two groups. Gross changes were observed in a few cases and no case demonstrated histologic modifications. Conclusions: Petrolatum ointment is as effective as 2{\%} testosterone in the treatment of vulvar lichen sclerosus.",
keywords = "Lichen sclerosus, Testosterone, Topical treatment, Vulva, Vulvar dystrophy",
author = "M. Sideri and M. Origoni and L. Spinaci and A. Ferrari",
year = "1994",
doi = "10.1016/0020-7292(94)90309-3",
language = "English",
volume = "46",
pages = "53--56",
journal = "International Journal of Gynecology and Obstetrics",
issn = "0020-7292",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Topical testosterone in the treatment of vulvar lichen sclerosus

AU - Sideri, M.

AU - Origoni, M.

AU - Spinaci, L.

AU - Ferrari, A.

PY - 1994

Y1 - 1994

N2 - Objectives: Comparison between 2% testosterone propionate and petrolatum ointment in the treatment of vulvar lichen sclerosus in a randomized, double-blind, controlled clinical study. Methods: Fifty-eight consecutive patients with histologically confirmed vulvar lichen sclerosus were enrolled. They underwent a 1-year period of topical treatment with either medication, with clinical evaluations of symptoms and gross appearance at 2-month intervals, followed by histological evaluation at the end of the treatment period. Statistical analysis was performed according to the chisquared test and the Student-Newman-Keuls test. Results: A substantial improvement in symptoms was achieved in 20 (66.6%) patients in the testosterone group and in 21 (75%) patients in the placebo group. No statistical differences were observed between the two groups. Gross changes were observed in a few cases and no case demonstrated histologic modifications. Conclusions: Petrolatum ointment is as effective as 2% testosterone in the treatment of vulvar lichen sclerosus.

AB - Objectives: Comparison between 2% testosterone propionate and petrolatum ointment in the treatment of vulvar lichen sclerosus in a randomized, double-blind, controlled clinical study. Methods: Fifty-eight consecutive patients with histologically confirmed vulvar lichen sclerosus were enrolled. They underwent a 1-year period of topical treatment with either medication, with clinical evaluations of symptoms and gross appearance at 2-month intervals, followed by histological evaluation at the end of the treatment period. Statistical analysis was performed according to the chisquared test and the Student-Newman-Keuls test. Results: A substantial improvement in symptoms was achieved in 20 (66.6%) patients in the testosterone group and in 21 (75%) patients in the placebo group. No statistical differences were observed between the two groups. Gross changes were observed in a few cases and no case demonstrated histologic modifications. Conclusions: Petrolatum ointment is as effective as 2% testosterone in the treatment of vulvar lichen sclerosus.

KW - Lichen sclerosus

KW - Testosterone

KW - Topical treatment

KW - Vulva

KW - Vulvar dystrophy

UR - http://www.scopus.com/inward/record.url?scp=0028021489&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028021489&partnerID=8YFLogxK

U2 - 10.1016/0020-7292(94)90309-3

DO - 10.1016/0020-7292(94)90309-3

M3 - Article

C2 - 7805984

AN - SCOPUS:0028021489

VL - 46

SP - 53

EP - 56

JO - International Journal of Gynecology and Obstetrics

JF - International Journal of Gynecology and Obstetrics

SN - 0020-7292

IS - 1

ER -