Topical use of calcitriol 3 μg/g ointment in the treatment of mild-to-moderate psoriasis: Results from an open-label study

I. Carboni, C. De Felice, A. Bergamin, S. Chimenti

Research output: Contribution to journalArticle

Abstract

Background: Calcitriol is the active metabolite and hormonal analogue of vitamin D 3. It is widely used for the topical treatment of psoriasis showing good tolerability and effectiveness. Objectives: To assess the efficacy, tolerability and safety of calcitriol 3 μg/g ointment in mild to moderate plaque psoriasis involving sensitive areas. Methods: Sixty patients with a body surface area <35% were enrolled into a prospective open label clinical study. Patients were treated for 12 weeks with a twice daily calcitriol 3 μg/g topical ointment application. Efficacy and safety were assessed during the therapy and during a 6-month follow-up period. Results: The study demonstrated a high clinical remission rate which progressively increased throughout therapy (11.6% at week 4, 28.3% at week 8 and 63.3% at week 12). No serious adverse events and clinically relevant changes of calcium/phosphorus homeostasis were reported. Conclusions: The study suggests that calcitriol 3 μg/g ointment, applied twice daily, is an effective topical treatment for chronic psoriatic plaques involving less than 35% of the body surface and sensitive areas.

Original languageEnglish
Pages (from-to)11-13
Number of pages3
JournalJournal of the European Academy of Dermatology and Venereology
Volume19
Issue numberSUPPL. 3
DOIs
Publication statusPublished - Nov 2005

Keywords

  • Calcitriol
  • Plaque psoriasis
  • Sensitive areas
  • Vitamin D derivatives

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

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