Topical versus intravenous tranexamic acid in total knee arthroplasty

Sanjay Meena, Francesco Benazzo, Saumitra Dwivedi, Matteo Ghiara

Research output: Contribution to journalArticlepeer-review


METHODS: The literature search was conducted using PubMed, Cochrane Library, MEDLINE, EMBASE and China National Knowledge Infrastructure (CNKI). All randomized controlled trials evaluating the effectiveness of topical route and IV route of TXA administration were included.

RESULTS: Eight randomized clinical trials comprising of 857 patients were included in this analysis. We found no statistically significant difference in terms of total blood loss, drain output, transfusion requirement, thromboembolic complication, tourniquet time and surgical duration.

CONCLUSION: Topical TXA has a similar efficacy to IV-TXA in reducing total blood loss, drain output, transfusion rate and haemoglobin drop without any increase in thromboembolic complications.

PURPOSE: The aim of this meta-analysis is to examine the efficacy and safety of intra-articular tranexamic acid (TXA) when compared to intravenous (IV) route.

Original languageEnglish
JournalJournal of orthopaedic surgery (Hong Kong)
Issue number1
Publication statusPublished - Jan 1 2017


  • knee
  • knee arthroplasty
  • knee replacement
  • systematic review
  • tranexamic acid

ASJC Scopus subject areas

  • Surgery


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