Topiramate as add-on drug in children, adolescents and young adults with Lennox-Gastaut syndrome: An Italian multicentric study

Giangennaro Coppola, Graziella Caliendo, Pierangelo Veggiotti, Antonino Romeo, Gaetano Tortorella, Pasquale De Marco, Antonio Pascotto

Research output: Contribution to journalArticle

Abstract

The purpose of the study was to evaluate the efficacy and safety of topiramate (TPM) as adjunctive therapy in children, adolescents and young adults with Lennox-Gastaut syndrome (LGS). We performed a prospective open label add-on study in 45 patients (age 4-34 years, mean 15.9 years) with LGS and refractory seizures. TPM was added to one or two other baseline drugs and the efficacy was rated according to seizure type and frequency. TPM was initiated at the daily dose of 0.5-1 mg/kg, followed by a 2-week titration at increments of 1-3 mg/kg/24 h, up to a maximum daily dose of 12 mg/kg. After a mean period of 15.8 months of treatment (range 3-98 months), at a mean dose of 4.1 mg/kg/24 h (range 1.4-12 mg/kg), 18 patients (40%) had a seizure reduction more than 50%. TPM appeared to be effective mainly in major seizures (drop attacks, tonic and tonic-clonic seizures). Mild to moderate adverse events were present in 24 patients (53.3%), mostly represented by drowsiness, nervousness, hyporexia with or without weight loss and cognitive dulling. In conclusion, TPM adjunctive therapy reduced the number of drop attacks and major motor seizures in 40% of patients with LGS and produced only mild or moderate adverse events.

Original languageEnglish
Pages (from-to)147-153
Number of pages7
JournalEpilepsy Research
Volume51
Issue number1-2
DOIs
Publication statusPublished - Sep 2002

Keywords

  • Adolescents and young adults
  • Children
  • Lennox-Gastaut syndrome
  • Therapy
  • Topiramate

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

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    Coppola, G., Caliendo, G., Veggiotti, P., Romeo, A., Tortorella, G., De Marco, P., & Pascotto, A. (2002). Topiramate as add-on drug in children, adolescents and young adults with Lennox-Gastaut syndrome: An Italian multicentric study. Epilepsy Research, 51(1-2), 147-153. https://doi.org/10.1016/S0920-1211(02)00103-1