Topiramate-associated worsening symptoms in a patient with familial hemiplegic migraine

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Topiramate has been shown to be highly effective for preventive treatment of migraine and its use has been significantly increased in the last few years. However, around 10% of migraineurs develop a worsening of their symptoms while on topiramate. We report a 33-year-old woman with familial hemiplegic migraine (FHM) who experienced worsening of her symptoms following repeated topiramate intake. Withdrawal of the drug rapidly constantly induced resolution of the symptoms. This is the first report of topiramate-associated worsening symptoms in FHM. It is important to be aware of this phenomenon, as topiramate is worldwide-used drug for migraine treatment.

Original languageEnglish
Pages (from-to)194-195
Number of pages2
JournalJournal of the Neurological Sciences
Issue number1-2
Publication statusPublished - Sep 15 2008


  • Adverse effect
  • Hemiplegic migraine
  • Topiramate

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology


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