Topiramate: Effect on EEG interictal abnormalities and background activity in patients affected by focal epilepsy

Fabio Placidi, Mario Tombini, Andrea Romigi, Luigi Bianchi, Francesca Izzi, Francesca Sperli, Donatella Mattia, Angela Cervellino, Maria Grazia Marciani

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To evaluate the effects of topiramate (TPM) on interictal epileptiform abnormalities (IEA) and background activity by means of a computerized EEG analysis, in adult patients affected by focal epilepsy, with or without secondarily generalization, treated with TPM as adjunctive therapy or monotherapy. Methods: Twenty-four patients affected by symptomatic or cryptogenic focal epilepsy underwent long-term video-EEG recording before and after TPM addition (mean dose 175±25mg per day). Results: TPM addition induced a significant reduction of both partial and secondarily generalized tonic-clonic (SGTC) seizures; treatment responder patients (seizure reduction≥50%) were 19 out of 24 patients (79.1%), of whom 5 were seizure-free. Quantitative analysis of IEA showed a significant decrease in the mean number of spikes/10min during TPM therapy (4.2±4.2 versus 2.2±4.4; P

Original languageEnglish
Pages (from-to)43-52
Number of pages10
JournalEpilepsy Research
Volume58
Issue number1
DOIs
Publication statusPublished - Jan 2004

Keywords

  • Background activity
  • EEG
  • Focal epilepsy
  • Interictal epileptiform abnormalities (IEA)
  • Topiramate

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

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