Topiramate in frontal lobe epilepsy

A. Verrotti, V. Sofia, E. Franzoni, G. Coppola, R. Manco, G. L. Ciambra, S. Savasta, F. Chiarelli, P. Iannetti

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background - Frontal lobe epilepsy (FLE) is a type of epilepsy that is difficult to treat and there are few studies about the use of topiramate (TPM). Aim of the study - To evaluate the efficacy and tolerability of TPM monotherapy in FLE. Methods - The study group consisted of 55 (33 male; 22 female) patients. TPM was administered as a first drug (n = 16) or converted after previous treatment (n = 39). All patients were followed every 3 months for at least 1 year. The patients were subdivided into two groups: 'newly diagnosed' patients and 'difficult-to-treat' patients. Results - Overall, all patients completed the 1-year study. At the end of follow-up, 10 patients showed disappearance of seizures and 33 patients showed improvement in seizure frequency. In particular, among the newly diagnosed patients 6/16 patients showed complete cessation of seizures and 5/16 patients showed very good response; in the other group, 4/39 patients showed complete cessation and 4/39 patients showed a very good response. No patients of both groups had worsening of seizures. No treatment-limiting adverse events associated with TPM were reported. Conclusions - TPM is effective in newly diagnosed patients with FLE; TPM can be considered for the treatment of FLE.

Original languageEnglish
Pages (from-to)132-135
Number of pages4
JournalActa Neurologica Scandinavica
Volume115
Issue number2
DOIs
Publication statusPublished - Feb 2007

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Frontal Lobe Epilepsy
Seizures
topiramate

Keywords

  • Antiepileptic drugs
  • Frontal lobe epilepsy
  • Monotherapy
  • Topiramate

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Verrotti, A., Sofia, V., Franzoni, E., Coppola, G., Manco, R., Ciambra, G. L., ... Iannetti, P. (2007). Topiramate in frontal lobe epilepsy. Acta Neurologica Scandinavica, 115(2), 132-135. https://doi.org/10.1111/j.1600-0404.2006.00758.x

Topiramate in frontal lobe epilepsy. / Verrotti, A.; Sofia, V.; Franzoni, E.; Coppola, G.; Manco, R.; Ciambra, G. L.; Savasta, S.; Chiarelli, F.; Iannetti, P.

In: Acta Neurologica Scandinavica, Vol. 115, No. 2, 02.2007, p. 132-135.

Research output: Contribution to journalArticle

Verrotti, A, Sofia, V, Franzoni, E, Coppola, G, Manco, R, Ciambra, GL, Savasta, S, Chiarelli, F & Iannetti, P 2007, 'Topiramate in frontal lobe epilepsy', Acta Neurologica Scandinavica, vol. 115, no. 2, pp. 132-135. https://doi.org/10.1111/j.1600-0404.2006.00758.x
Verrotti A, Sofia V, Franzoni E, Coppola G, Manco R, Ciambra GL et al. Topiramate in frontal lobe epilepsy. Acta Neurologica Scandinavica. 2007 Feb;115(2):132-135. https://doi.org/10.1111/j.1600-0404.2006.00758.x
Verrotti, A. ; Sofia, V. ; Franzoni, E. ; Coppola, G. ; Manco, R. ; Ciambra, G. L. ; Savasta, S. ; Chiarelli, F. ; Iannetti, P. / Topiramate in frontal lobe epilepsy. In: Acta Neurologica Scandinavica. 2007 ; Vol. 115, No. 2. pp. 132-135.
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