Topiramate plus paroxetine in treatment-resistant obsessive-compulsive disorder

Eric Hollander, Bernardo Dell'Osso

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

We report a case of treatment-resistant obsessive-compulsive disorder (OCD) that was successfully treated with a pharmacological augmentation of topiramate plus paroxetine. The patient, a 45-year-old woman, was on a stable dose of paroxetine (40 mg/day) when she was started on topiramate (up to 150 mg/day). After 9 weeks of this treatment, her clinical condition remarkably improved, as indicated by a significant decrease of the evaluation scales (Yale-Brown Obsessive-Compulsive Scale and Clinical Global Impression Scale). Our case suggests that topiramate might be beneficial in augmentation with selective serotonin reuptake inhibitors in patients with treatment-resistant OCD, although further investigations are warranted to confirm our findings.

Original languageEnglish
Pages (from-to)189-191
Number of pages3
JournalInternational Clinical Psychopharmacology
Volume21
Issue number3
DOIs
Publication statusPublished - May 2006

Fingerprint

Paroxetine
Obsessive-Compulsive Disorder
Serotonin Uptake Inhibitors
Therapeutics
Pharmacology
topiramate

Keywords

  • Augmentation
  • Obsessive-compulsive disorder
  • Paroxetine
  • Topiramate
  • Treatment-resistant

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Topiramate plus paroxetine in treatment-resistant obsessive-compulsive disorder. / Hollander, Eric; Dell'Osso, Bernardo.

In: International Clinical Psychopharmacology, Vol. 21, No. 3, 05.2006, p. 189-191.

Research output: Contribution to journalArticle

@article{92499004e1d1436caa46232a2bf18abc,
title = "Topiramate plus paroxetine in treatment-resistant obsessive-compulsive disorder",
abstract = "We report a case of treatment-resistant obsessive-compulsive disorder (OCD) that was successfully treated with a pharmacological augmentation of topiramate plus paroxetine. The patient, a 45-year-old woman, was on a stable dose of paroxetine (40 mg/day) when she was started on topiramate (up to 150 mg/day). After 9 weeks of this treatment, her clinical condition remarkably improved, as indicated by a significant decrease of the evaluation scales (Yale-Brown Obsessive-Compulsive Scale and Clinical Global Impression Scale). Our case suggests that topiramate might be beneficial in augmentation with selective serotonin reuptake inhibitors in patients with treatment-resistant OCD, although further investigations are warranted to confirm our findings.",
keywords = "Augmentation, Obsessive-compulsive disorder, Paroxetine, Topiramate, Treatment-resistant",
author = "Eric Hollander and Bernardo Dell'Osso",
year = "2006",
month = "5",
doi = "10.1097/01.yic.0000199453.54799.cc",
language = "English",
volume = "21",
pages = "189--191",
journal = "International Clinical Psychopharmacology",
issn = "0268-1315",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Topiramate plus paroxetine in treatment-resistant obsessive-compulsive disorder

AU - Hollander, Eric

AU - Dell'Osso, Bernardo

PY - 2006/5

Y1 - 2006/5

N2 - We report a case of treatment-resistant obsessive-compulsive disorder (OCD) that was successfully treated with a pharmacological augmentation of topiramate plus paroxetine. The patient, a 45-year-old woman, was on a stable dose of paroxetine (40 mg/day) when she was started on topiramate (up to 150 mg/day). After 9 weeks of this treatment, her clinical condition remarkably improved, as indicated by a significant decrease of the evaluation scales (Yale-Brown Obsessive-Compulsive Scale and Clinical Global Impression Scale). Our case suggests that topiramate might be beneficial in augmentation with selective serotonin reuptake inhibitors in patients with treatment-resistant OCD, although further investigations are warranted to confirm our findings.

AB - We report a case of treatment-resistant obsessive-compulsive disorder (OCD) that was successfully treated with a pharmacological augmentation of topiramate plus paroxetine. The patient, a 45-year-old woman, was on a stable dose of paroxetine (40 mg/day) when she was started on topiramate (up to 150 mg/day). After 9 weeks of this treatment, her clinical condition remarkably improved, as indicated by a significant decrease of the evaluation scales (Yale-Brown Obsessive-Compulsive Scale and Clinical Global Impression Scale). Our case suggests that topiramate might be beneficial in augmentation with selective serotonin reuptake inhibitors in patients with treatment-resistant OCD, although further investigations are warranted to confirm our findings.

KW - Augmentation

KW - Obsessive-compulsive disorder

KW - Paroxetine

KW - Topiramate

KW - Treatment-resistant

UR - http://www.scopus.com/inward/record.url?scp=33646715104&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646715104&partnerID=8YFLogxK

U2 - 10.1097/01.yic.0000199453.54799.cc

DO - 10.1097/01.yic.0000199453.54799.cc

M3 - Article

VL - 21

SP - 189

EP - 191

JO - International Clinical Psychopharmacology

JF - International Clinical Psychopharmacology

SN - 0268-1315

IS - 3

ER -