TY - JOUR
T1 - Topiramate treatment for nocturnal frontal lobe epilepsy
AU - Oldani, Alessandro
AU - Manconi, Mauro
AU - Zucconi, Marco
AU - Martinelli, Cristina
AU - Ferini-Strambi, Luigi
PY - 2006/12
Y1 - 2006/12
N2 - Purpose: Aim of this study was to evaluate the efficacy and tolerability of the antiepileptic drug topiramate (TPM) in a sample of patients with nocturnal frontal lobe epilepsy (NFLE). Methods: A 24 patients with video-polysomnographically confirmed NFLE received topiramate as single or add-on therapy. They all completed diaries concerning the seizures frequency and complexity and underwent to periodic follow-up visits. We classified the patients as: seizure-free, responders or non-responders. Results: 15 M; 9 F; mean age 29.3 ± 10.4 years. The video-polysomnographic recordings showed a wide spectrum of seizures, ranging from repeated stereotypic brief motor attacks to prolonged attacks, with complex and bizarre behaviour; the recorded episodes occurred during non-REM sleep, both stage 2 and stage 3-4. The EEG during wakefulness was normal in all the patients, while seven of them showed epileptiform abnormalities during polysomnography. TPM was administered as single or add-on therapy from 50 to 300 mg daily at bedtime. The follow-up duration ranged from 6 months to 6 years. The patients were classified as: seizure-free = 6 (25%); responders (reduction of at least 50% of seizures) = 15 (62.5%); non-responders = 3 (12.5%). The adverse events were: weight loss (6 pts, 25%); paresthesias (3 pts, 12.5%); speech dysfunction (2 pts, 8.3%). All the adverse events disappeared within 3 months. Conclusions: In our experience, TPM seems to be effective in about 90% of patients with NFLE. Few of them experienced transitory adverse events. TPM could be included in the options for patients with this form of epilepsy.
AB - Purpose: Aim of this study was to evaluate the efficacy and tolerability of the antiepileptic drug topiramate (TPM) in a sample of patients with nocturnal frontal lobe epilepsy (NFLE). Methods: A 24 patients with video-polysomnographically confirmed NFLE received topiramate as single or add-on therapy. They all completed diaries concerning the seizures frequency and complexity and underwent to periodic follow-up visits. We classified the patients as: seizure-free, responders or non-responders. Results: 15 M; 9 F; mean age 29.3 ± 10.4 years. The video-polysomnographic recordings showed a wide spectrum of seizures, ranging from repeated stereotypic brief motor attacks to prolonged attacks, with complex and bizarre behaviour; the recorded episodes occurred during non-REM sleep, both stage 2 and stage 3-4. The EEG during wakefulness was normal in all the patients, while seven of them showed epileptiform abnormalities during polysomnography. TPM was administered as single or add-on therapy from 50 to 300 mg daily at bedtime. The follow-up duration ranged from 6 months to 6 years. The patients were classified as: seizure-free = 6 (25%); responders (reduction of at least 50% of seizures) = 15 (62.5%); non-responders = 3 (12.5%). The adverse events were: weight loss (6 pts, 25%); paresthesias (3 pts, 12.5%); speech dysfunction (2 pts, 8.3%). All the adverse events disappeared within 3 months. Conclusions: In our experience, TPM seems to be effective in about 90% of patients with NFLE. Few of them experienced transitory adverse events. TPM could be included in the options for patients with this form of epilepsy.
KW - NFLE
KW - Sleep
KW - Topiramate
UR - http://www.scopus.com/inward/record.url?scp=33750492942&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750492942&partnerID=8YFLogxK
U2 - 10.1016/j.seizure.2006.07.002
DO - 10.1016/j.seizure.2006.07.002
M3 - Article
C2 - 16973383
AN - SCOPUS:33750492942
VL - 15
SP - 649
EP - 652
JO - Seizure : the journal of the British Epilepsy Association
JF - Seizure : the journal of the British Epilepsy Association
SN - 1059-1311
IS - 8
ER -