Topography and biological role of integrins in human skin

Pier Carlo Marchisio, Livio Trusolino, Michele De Luca

Research output: Contribution to journalArticle

Abstract

We report the topography of integrins in the human epidermis and in cultured human keratinocytes. Both in situ and in vitro β1 integrins are exposed at the cell-cell adhesion interface while β4 is located on the basal membrane in contact with the basal lamina. Such defined sorting identifies discrete cell membrane domains that may be involved in defining, building up, and maintaining epithelial cell polarity. The distribution of integrins is deeply altered in hyperproliferative states like those occurring in several experimental conditions and in epidermal diseases.

Original languageEnglish
Pages (from-to)353-360
Number of pages8
JournalMicroscopy Research and Technique
Volume38
Issue number4
DOIs
Publication statusPublished - 1997

Keywords

  • Basal membrane
  • Integrins
  • Keratinocytes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Anatomy
  • Instrumentation

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