Torque Teno Virus-Cause of Viral Liver Disease Following Liver Transplantation: A Case Report

F. Piaggio, F. Dodi, G. Bottino, E. Andorno, R. Gentile, C. Ferrari, G. Barabino, A. Giannone, G. Immordino, M. Miggino, A. Magoni Rossi, E. Moraglia, G. Gasloli, M. Gelli, R. Ferrante, N. Morelli, M. Casaccia, U. Valente

Research output: Contribution to journalArticle

Abstract

Torque Teno Virus (TTV), a nonenveloped human virus of the Circoviridae family, is hepatotropic, causing liver damage, cirrhosis, and, rarely, fulminant hepatitis. It prevails in 10% to 75% of blood donors due to environmental differences, independent of chronic hepatitis B virus (HBV)/HCV hepatitis, cryptogenic cirrhosis, alcoholic cirrhosis, and in fulminant hepatitis non-A-G. Reports about the efficacy of clinical alpha interferon are rare. In July 2007, a 65-year-old man who was serologically negative for A-E viruses presented with acute liver failure due to a ruptured hepatic artery aneurysm and underwent orthotopic liver transplantation (OLT). Immunosuppression was based on cyclosporine and steroids. At postoperative day 20, there was persistent hypertransaminasemia with otherwise normal liver function. A percutaneous hepatic biopsy documented pattern suggestive of a viral etiology. Multiple tests for hepatotropic viruses in the donor and the recipient from the pre- and post-OLT periods remained negative. Only the TTV qualitative test, assessed by polymerase chain reaction (PCR) on patient sera, was positive. Immunosuppressive therapy was not changed; no antiviral therapy was undertaken. At 6 months posttransplantation, transaminase levels spontaneously normalized and the clinical situation was unchanged. No complications were observed; the patient is in good clinical condition. No graft rejection was observed. In histologically proven non-A-E viral hepatitis, it is important to consider TTV as an incidental pathogenic agent. It may be useful to extend virological tests to TTV among transplant recipients and donors and to gain further knowledge about this virus.

Original languageEnglish
Pages (from-to)1378-1379
Number of pages2
JournalTransplantation Proceedings
Volume41
Issue number4
DOIs
Publication statusPublished - May 2009

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Torque teno virus
Virus Diseases
Liver Transplantation
Liver Diseases
Hepatitis
Viruses
Circoviridae
Tissue Donors
Hepatitis E
Alcoholic Liver Cirrhosis
Acute Liver Failure
Liver
Hepatic Artery
Chronic Hepatitis B
Graft Rejection
Immunosuppressive Agents
Transaminases
Blood Donors
Hepatitis B virus
Interferon-alpha

ASJC Scopus subject areas

  • Surgery
  • Transplantation
  • Medicine(all)

Cite this

Piaggio, F., Dodi, F., Bottino, G., Andorno, E., Gentile, R., Ferrari, C., ... Valente, U. (2009). Torque Teno Virus-Cause of Viral Liver Disease Following Liver Transplantation: A Case Report. Transplantation Proceedings, 41(4), 1378-1379. https://doi.org/10.1016/j.transproceed.2009.03.047

Torque Teno Virus-Cause of Viral Liver Disease Following Liver Transplantation : A Case Report. / Piaggio, F.; Dodi, F.; Bottino, G.; Andorno, E.; Gentile, R.; Ferrari, C.; Barabino, G.; Giannone, A.; Immordino, G.; Miggino, M.; Magoni Rossi, A.; Moraglia, E.; Gasloli, G.; Gelli, M.; Ferrante, R.; Morelli, N.; Casaccia, M.; Valente, U.

In: Transplantation Proceedings, Vol. 41, No. 4, 05.2009, p. 1378-1379.

Research output: Contribution to journalArticle

Piaggio, F, Dodi, F, Bottino, G, Andorno, E, Gentile, R, Ferrari, C, Barabino, G, Giannone, A, Immordino, G, Miggino, M, Magoni Rossi, A, Moraglia, E, Gasloli, G, Gelli, M, Ferrante, R, Morelli, N, Casaccia, M & Valente, U 2009, 'Torque Teno Virus-Cause of Viral Liver Disease Following Liver Transplantation: A Case Report', Transplantation Proceedings, vol. 41, no. 4, pp. 1378-1379. https://doi.org/10.1016/j.transproceed.2009.03.047
Piaggio, F. ; Dodi, F. ; Bottino, G. ; Andorno, E. ; Gentile, R. ; Ferrari, C. ; Barabino, G. ; Giannone, A. ; Immordino, G. ; Miggino, M. ; Magoni Rossi, A. ; Moraglia, E. ; Gasloli, G. ; Gelli, M. ; Ferrante, R. ; Morelli, N. ; Casaccia, M. ; Valente, U. / Torque Teno Virus-Cause of Viral Liver Disease Following Liver Transplantation : A Case Report. In: Transplantation Proceedings. 2009 ; Vol. 41, No. 4. pp. 1378-1379.
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