Tortuosity, Recurrent Segments, and Bridging of the Epicardial Coronary Arteries in Patients With the Takotsubo Syndrome

Luca Arcari, Luca Rosario Limite, Luca Cacciotti, Alessandro Alonzo, Maria Beatrice Musumeci, Ilaria Passaseo, Giuseppe Marazzi, Andrea Berni, Gerardo Ansalone, Massimo Volpe, Camillo Autore

Research output: Contribution to journalArticle

Abstract

Myocardial bridging (MB) and a long recurrent wraparound left anterior descending artery (wrap-LAD) are coronary anatomic variants that have been recently suggested to be associated with takotsubo syndrome (TS). Until now, coronary artery tortuosity (CAT) has never been investigated in this setting. Our study sought to evaluate the prevalence of the aforementioned anatomic variants in a large population with TS. In this retrospective angiographic study, 109 patients with TS were compared with 109 age- and gender-matched subjects without coronary artery disease, valve heart disease, or cardiomyopathy. CAT was identified by ≥3 consecutive curvatures ≥90° (criteria 1) or by ≥2 consecutive curvatures ≥180° (criteria 2). Wrap-LAD was defined if any part of the vessel outreached the apex of the left ventricle and MB as the presence of a milking effect or a step-up and step-down phenomenon. An anatomic variant was found in 79 patients with TS (72%) and in 48 controls (44%) (p <0.001). CAT in at least 1 vessel (criteria 1: 49% vs 20%, p <0.001; criteria 2: 38% vs 13%, p <0.001), ≥2 vessels (criteria 2: 14% vs 3%, p = 0.005), and wrap-LAD (41% vs 27%, p = 0.02) were significantly more frequent in patients with TS than in controls. The prevalence of MB (9% vs 5%, p = 0.18) did not differ between groups. In conclusion, CAT and wrap-LAD have higher prevalence in patients with TS than in matched controls. These findings could support the hypothesis that anatomic variants might act as potential pathogenic substrates in TS.

Original languageEnglish
Pages (from-to)243-248
Number of pages6
JournalAmerican Journal of Cardiology
Volume119
Issue number2
DOIs
Publication statusPublished - Jan 15 2017

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Takotsubo Cardiomyopathy
Coronary Vessels
Myocardial Bridging
Arteries
Heart Valve Diseases
Cardiomyopathies
Heart Ventricles
Coronary Artery Disease
Retrospective Studies

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Tortuosity, Recurrent Segments, and Bridging of the Epicardial Coronary Arteries in Patients With the Takotsubo Syndrome. / Arcari, Luca; Limite, Luca Rosario; Cacciotti, Luca; Alonzo, Alessandro; Musumeci, Maria Beatrice; Passaseo, Ilaria; Marazzi, Giuseppe; Berni, Andrea; Ansalone, Gerardo; Volpe, Massimo; Autore, Camillo.

In: American Journal of Cardiology, Vol. 119, No. 2, 15.01.2017, p. 243-248.

Research output: Contribution to journalArticle

Arcari, L, Limite, LR, Cacciotti, L, Alonzo, A, Musumeci, MB, Passaseo, I, Marazzi, G, Berni, A, Ansalone, G, Volpe, M & Autore, C 2017, 'Tortuosity, Recurrent Segments, and Bridging of the Epicardial Coronary Arteries in Patients With the Takotsubo Syndrome', American Journal of Cardiology, vol. 119, no. 2, pp. 243-248. https://doi.org/10.1016/j.amjcard.2016.09.055
Arcari, Luca ; Limite, Luca Rosario ; Cacciotti, Luca ; Alonzo, Alessandro ; Musumeci, Maria Beatrice ; Passaseo, Ilaria ; Marazzi, Giuseppe ; Berni, Andrea ; Ansalone, Gerardo ; Volpe, Massimo ; Autore, Camillo. / Tortuosity, Recurrent Segments, and Bridging of the Epicardial Coronary Arteries in Patients With the Takotsubo Syndrome. In: American Journal of Cardiology. 2017 ; Vol. 119, No. 2. pp. 243-248.
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AB - Myocardial bridging (MB) and a long recurrent wraparound left anterior descending artery (wrap-LAD) are coronary anatomic variants that have been recently suggested to be associated with takotsubo syndrome (TS). Until now, coronary artery tortuosity (CAT) has never been investigated in this setting. Our study sought to evaluate the prevalence of the aforementioned anatomic variants in a large population with TS. In this retrospective angiographic study, 109 patients with TS were compared with 109 age- and gender-matched subjects without coronary artery disease, valve heart disease, or cardiomyopathy. CAT was identified by ≥3 consecutive curvatures ≥90° (criteria 1) or by ≥2 consecutive curvatures ≥180° (criteria 2). Wrap-LAD was defined if any part of the vessel outreached the apex of the left ventricle and MB as the presence of a milking effect or a step-up and step-down phenomenon. An anatomic variant was found in 79 patients with TS (72%) and in 48 controls (44%) (p <0.001). CAT in at least 1 vessel (criteria 1: 49% vs 20%, p <0.001; criteria 2: 38% vs 13%, p <0.001), ≥2 vessels (criteria 2: 14% vs 3%, p = 0.005), and wrap-LAD (41% vs 27%, p = 0.02) were significantly more frequent in patients with TS than in controls. The prevalence of MB (9% vs 5%, p = 0.18) did not differ between groups. In conclusion, CAT and wrap-LAD have higher prevalence in patients with TS than in matched controls. These findings could support the hypothesis that anatomic variants might act as potential pathogenic substrates in TS.

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