Irradiazione corporea totale e trapianto di midollo osseo.

Translated title of the contribution: Total body irradiation and bone marrow transplant

C. Martinenghi, E. Villa, V. Fossati, S. Beatrice

Research output: Contribution to journalArticle

Abstract

Any malignancy, mainly hematological, may be sensitive (with complete remission) to high-dose chemo and/or radiotherapy. The dose of most antineoplastic agents is limited by the toxicity to the normal marrow. The availability of marrow for transplantation (allogenic, syngenic or autologous), and the capability of reconstituting hematopoietic function, makes it possible to administer chemoradiotherapy in supralethal doses in an effort to kill a greater fraction of the malignant cells. Total Body Irradiation is used both to eradicate the malignant cells and to suppress host immune reactivity enough to prevent rejection of allogenic marrow. The transplanted allogenic marrow can also exert an antitumor effect. A survey of radiobiological studies undertaken is presented and preliminary results of a series of patients treated with TBI at ISSR are discussed.

Original languageItalian
Pages (from-to)705-714
Number of pages10
JournalRadiologia Medica
Volume72
Issue number10
Publication statusPublished - Oct 1986

Fingerprint

Whole-Body Irradiation
Bone Marrow
Transplants
Isogeneic Transplantation
Autologous Transplantation
Homologous Transplantation
Chemoradiotherapy
Hematologic Neoplasms
Antineoplastic Agents
Radiotherapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Martinenghi, C., Villa, E., Fossati, V., & Beatrice, S. (1986). Irradiazione corporea totale e trapianto di midollo osseo. Radiologia Medica, 72(10), 705-714.

Irradiazione corporea totale e trapianto di midollo osseo. / Martinenghi, C.; Villa, E.; Fossati, V.; Beatrice, S.

In: Radiologia Medica, Vol. 72, No. 10, 10.1986, p. 705-714.

Research output: Contribution to journalArticle

Martinenghi, C, Villa, E, Fossati, V & Beatrice, S 1986, 'Irradiazione corporea totale e trapianto di midollo osseo.', Radiologia Medica, vol. 72, no. 10, pp. 705-714.
Martinenghi C, Villa E, Fossati V, Beatrice S. Irradiazione corporea totale e trapianto di midollo osseo. Radiologia Medica. 1986 Oct;72(10):705-714.
Martinenghi, C. ; Villa, E. ; Fossati, V. ; Beatrice, S. / Irradiazione corporea totale e trapianto di midollo osseo. In: Radiologia Medica. 1986 ; Vol. 72, No. 10. pp. 705-714.
@article{4adc9aa2411640be99bdf40235a374c3,
title = "Irradiazione corporea totale e trapianto di midollo osseo.",
abstract = "Any malignancy, mainly hematological, may be sensitive (with complete remission) to high-dose chemo and/or radiotherapy. The dose of most antineoplastic agents is limited by the toxicity to the normal marrow. The availability of marrow for transplantation (allogenic, syngenic or autologous), and the capability of reconstituting hematopoietic function, makes it possible to administer chemoradiotherapy in supralethal doses in an effort to kill a greater fraction of the malignant cells. Total Body Irradiation is used both to eradicate the malignant cells and to suppress host immune reactivity enough to prevent rejection of allogenic marrow. The transplanted allogenic marrow can also exert an antitumor effect. A survey of radiobiological studies undertaken is presented and preliminary results of a series of patients treated with TBI at ISSR are discussed.",
author = "C. Martinenghi and E. Villa and V. Fossati and S. Beatrice",
year = "1986",
month = "10",
language = "Italian",
volume = "72",
pages = "705--714",
journal = "Radiologia Medica",
issn = "0033-8362",
publisher = "Springer-Verlag Italia s.r.l.",
number = "10",

}

TY - JOUR

T1 - Irradiazione corporea totale e trapianto di midollo osseo.

AU - Martinenghi, C.

AU - Villa, E.

AU - Fossati, V.

AU - Beatrice, S.

PY - 1986/10

Y1 - 1986/10

N2 - Any malignancy, mainly hematological, may be sensitive (with complete remission) to high-dose chemo and/or radiotherapy. The dose of most antineoplastic agents is limited by the toxicity to the normal marrow. The availability of marrow for transplantation (allogenic, syngenic or autologous), and the capability of reconstituting hematopoietic function, makes it possible to administer chemoradiotherapy in supralethal doses in an effort to kill a greater fraction of the malignant cells. Total Body Irradiation is used both to eradicate the malignant cells and to suppress host immune reactivity enough to prevent rejection of allogenic marrow. The transplanted allogenic marrow can also exert an antitumor effect. A survey of radiobiological studies undertaken is presented and preliminary results of a series of patients treated with TBI at ISSR are discussed.

AB - Any malignancy, mainly hematological, may be sensitive (with complete remission) to high-dose chemo and/or radiotherapy. The dose of most antineoplastic agents is limited by the toxicity to the normal marrow. The availability of marrow for transplantation (allogenic, syngenic or autologous), and the capability of reconstituting hematopoietic function, makes it possible to administer chemoradiotherapy in supralethal doses in an effort to kill a greater fraction of the malignant cells. Total Body Irradiation is used both to eradicate the malignant cells and to suppress host immune reactivity enough to prevent rejection of allogenic marrow. The transplanted allogenic marrow can also exert an antitumor effect. A survey of radiobiological studies undertaken is presented and preliminary results of a series of patients treated with TBI at ISSR are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0022793629&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022793629&partnerID=8YFLogxK

M3 - Articolo

C2 - 3534969

AN - SCOPUS:0022793629

VL - 72

SP - 705

EP - 714

JO - Radiologia Medica

JF - Radiologia Medica

SN - 0033-8362

IS - 10

ER -