Total body irradiation and high-dose melphalan with bone marrow transplantation at Istituto Nazionale Tumori, Milan, Italy

L. Gandola; F. Lombardi; S. Siena; M. Bregni; P. Piotti; E. Sverzellati; C. Stucchi; G. Bonadonna; A. M. Gianni; A. Lattuada

doi:10.1016/0167-8140(90)90186-Z

Total body irradiation and high-dose melphalan with bone marrow transplantation at Istituto Nazionale Tumori, Milan, Italy

L. Gandola, F. Lombardi, S. Siena, M. Bregni, P. Piotti, E. Sverzellati, C. Stucchi, G. Bonadonna, A. M. Gianni, A. Lattuada

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

The technique of total body irradiation (TBI) developed at Istituto Nazionale Tumori, Milan, Italy, is described. This technique consists of i) administration of 12.5 Gy and 14.85 Gy TBI for autologous and allogeneic bone marrow transplantation respectively; ii) in all cases in vivo dosimetry of absorbed TBI dose; and iii) radiation doses to lungs higher than previously described. As of June 1988, seventeen patients with Hodgkin's disease and four with lymphoblastic lymphoma received TBI and 120-180 mg/m² melphalan. Respiratory function was prospectively evaluated demonstrating moderate and transient reduction of pulmonary function.

Original language	English
Pages (from-to)	105-109
Number of pages	5
Journal	Radiotherapy and Oncology
Volume	18
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/0167-8140(90)90186-Z
Publication status	Published - 1990

Keywords

Fractionated total body irradiation
High dose melphalan
In vivo dosimetry

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Urology

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10.1016/0167-8140(90)90186-Z

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Total body irradiation and high-dose melphalan with bone marrow transplantation at Istituto Nazionale Tumori, Milan, Italy. / Gandola, L.; Lombardi, F.; Siena, S.; Bregni, M.; Piotti, P.; Sverzellati, E.; Stucchi, C.; Bonadonna, G.; Gianni, A. M.; Lattuada, A.

In: Radiotherapy and Oncology, Vol. 18, No. SUPPL. 1, 1990, p. 105-109.

Research output: Contribution to journal › Article › peer-review

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abstract = "The technique of total body irradiation (TBI) developed at Istituto Nazionale Tumori, Milan, Italy, is described. This technique consists of i) administration of 12.5 Gy and 14.85 Gy TBI for autologous and allogeneic bone marrow transplantation respectively; ii) in all cases in vivo dosimetry of absorbed TBI dose; and iii) radiation doses to lungs higher than previously described. As of June 1988, seventeen patients with Hodgkin's disease and four with lymphoblastic lymphoma received TBI and 120-180 mg/m2 melphalan. Respiratory function was prospectively evaluated demonstrating moderate and transient reduction of pulmonary function.",

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AU - Gandola, L.

AU - Lombardi, F.

AU - Siena, S.

AU - Bregni, M.

AU - Piotti, P.

AU - Sverzellati, E.

AU - Stucchi, C.

AU - Bonadonna, G.

AU - Gianni, A. M.

AU - Lattuada, A.

PY - 1990

Y1 - 1990

N2 - The technique of total body irradiation (TBI) developed at Istituto Nazionale Tumori, Milan, Italy, is described. This technique consists of i) administration of 12.5 Gy and 14.85 Gy TBI for autologous and allogeneic bone marrow transplantation respectively; ii) in all cases in vivo dosimetry of absorbed TBI dose; and iii) radiation doses to lungs higher than previously described. As of June 1988, seventeen patients with Hodgkin's disease and four with lymphoblastic lymphoma received TBI and 120-180 mg/m2 melphalan. Respiratory function was prospectively evaluated demonstrating moderate and transient reduction of pulmonary function.

AB - The technique of total body irradiation (TBI) developed at Istituto Nazionale Tumori, Milan, Italy, is described. This technique consists of i) administration of 12.5 Gy and 14.85 Gy TBI for autologous and allogeneic bone marrow transplantation respectively; ii) in all cases in vivo dosimetry of absorbed TBI dose; and iii) radiation doses to lungs higher than previously described. As of June 1988, seventeen patients with Hodgkin's disease and four with lymphoblastic lymphoma received TBI and 120-180 mg/m2 melphalan. Respiratory function was prospectively evaluated demonstrating moderate and transient reduction of pulmonary function.

KW - Fractionated total body irradiation

KW - High dose melphalan

KW - In vivo dosimetry

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Total body irradiation and high-dose melphalan with bone marrow transplantation at Istituto Nazionale Tumori, Milan, Italy

Abstract

Keywords

ASJC Scopus subject areas

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