Total body irradiation before allogeneic and autologous bone marrow transplantation: A ten year Genoa experience

Daniele Scarpati, Renzo Corvó, Francesco Frassoni, Marina Guenzi, Angelo Carella, Gino Santini, Vito Vitale, Paola Franzone

Research output: Contribution to journalArticle

Abstract

Since 1976 in Genoa, 291 TBI treatments were performed. Before allogeneic BMT, 1000 cGy/1 fx were prescribed in the first 22 patients, and then 990 cGy/3 fx/3 d in AML and CML, and the same or 1200 cGy/6 fx/3 d in ALL. Survival (S) and probability of remaining in remission (PRR) were 54% and 69% at 80 months in 80 AML; in 62 CML 45% and 60% at 60 months; in 69 ALL, 32% and 45% at 82 months. Differences in favour of higher doses and dose rates were observed and are presented. Before autologous BMT, 1000 cGy/1 fx were prescribed to AML and NHL, and 1200 cGy/3 fx/3 d to ALL patients. Disease free survival (DFS) was 71% and 13% at 82 months in 21 AML treated in first R and 9 ALL, respectively; 81 % at 32 months in 11 NHL treated in R.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalRadiotherapy and Oncology
Volume18
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 1990

Keywords

  • Allogeneic BMT
  • Autologous BMT
  • TBI

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Urology

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