Total cardiovascular risk, blood pressure variability and adrenergic overdrive in hypertension: Evidence, mechanisms and clinical implications

Guido Grassi, Michele Bombelli, Gianmaria Brambilla, Fosca Quarti Trevano, Raffaella Dell'Oro, Giuseppe Mancia

Research output: Contribution to journalArticle

Abstract

In hypertensive patients the risk of developing cardiovascular events and complications depends not only on the magnitude of the blood pressure elevation, but also, and to a consistent extent, on the presence of associated cardiovascular risk factors, concomitant disease and target organ damage. Recent findings suggest that also sympathetic overdrive and alterations in blood pressure variability (which are detected in hypertension) may participate at the increased cardiovascular risk of the patients with high blood pressure. This review will discuss the evidence collected over the past few years on the relationships between sympathetic activation and blood pressure variability and their impact on cardiovascular risk profile.

Original languageEnglish
Pages (from-to)333-338
Number of pages6
JournalCurrent Hypertension Reports
Volume14
Issue number4
DOIs
Publication statusPublished - Aug 2012

Keywords

  • Ambulatory blood pressure monitoring
  • Blood pressure variability
  • Cardiovascular risk
  • Cardiovascular risk factors
  • Hypertension
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Internal Medicine

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