Total HCV core antigen assay: A new marker of hepatitis C viremia for monitoring the progress of therapy

Alessandro R. Zanetti, Luisa Romanò, Maurizia Brunetto, Massimo Colombo, Giorgio Bellati, Charles Tackney

Research output: Contribution to journalArticle

Abstract

The ability of the total hepatitis C virus (HCV) core antigen assay was evaluated for monitoring the therapeutic responses of HCV-infected patients treated with interferon. The ability to detect and quantitate an independent structural protein component of HCV, in the presence of circulating antibodies, makes this assay a valuable new tool in diagnosis and treatment monitoring. Measurement of total core antigen showed a strong dynamic correlation with HCV RNA data and may serve as an alternative direct marker of viral infection. In addition, with the advent of additional treatment protocols, a rapid, reliable assay for changes in HCV load may permit more frequent patient assessment and tailoring of the therapeutic regimen.

Original languageEnglish
Pages (from-to)27-30
Number of pages4
JournalJournal of Medical Virology
Volume70
Issue number1
DOIs
Publication statusPublished - May 1 2003

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Viremia
Hepatitis C
Hepacivirus
Antigens
Therapeutics
Virus Diseases
Clinical Protocols
Interferons
RNA
Antibodies
Proteins

Keywords

  • HCV RNA
  • Hepatitis C
  • Total HCV core antigen

ASJC Scopus subject areas

  • Virology

Cite this

Total HCV core antigen assay : A new marker of hepatitis C viremia for monitoring the progress of therapy. / Zanetti, Alessandro R.; Romanò, Luisa; Brunetto, Maurizia; Colombo, Massimo; Bellati, Giorgio; Tackney, Charles.

In: Journal of Medical Virology, Vol. 70, No. 1, 01.05.2003, p. 27-30.

Research output: Contribution to journalArticle

Zanetti, Alessandro R. ; Romanò, Luisa ; Brunetto, Maurizia ; Colombo, Massimo ; Bellati, Giorgio ; Tackney, Charles. / Total HCV core antigen assay : A new marker of hepatitis C viremia for monitoring the progress of therapy. In: Journal of Medical Virology. 2003 ; Vol. 70, No. 1. pp. 27-30.
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