Total HCV core antigen assay: A new marker of hepatitis C viremia for monitoring the progress of therapy

Alessandro R. Zanetti; Luisa Romanò; Maurizia Brunetto; Massimo Colombo; Giorgio Bellati; Charles Tackney

doi:10.1002/jmv.10355

Total HCV core antigen assay: A new marker of hepatitis C viremia for monitoring the progress of therapy

Alessandro R. Zanetti, Luisa Romanò, Maurizia Brunetto, Massimo Colombo, Giorgio Bellati, Charles Tackney

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

The ability of the total hepatitis C virus (HCV) core antigen assay was evaluated for monitoring the therapeutic responses of HCV-infected patients treated with interferon. The ability to detect and quantitate an independent structural protein component of HCV, in the presence of circulating antibodies, makes this assay a valuable new tool in diagnosis and treatment monitoring. Measurement of total core antigen showed a strong dynamic correlation with HCV RNA data and may serve as an alternative direct marker of viral infection. In addition, with the advent of additional treatment protocols, a rapid, reliable assay for changes in HCV load may permit more frequent patient assessment and tailoring of the therapeutic regimen.

Original language	English
Pages (from-to)	27-30
Number of pages	4
Journal	Journal of Medical Virology
Volume	70
Issue number	1
DOIs	https://doi.org/10.1002/jmv.10355
Publication status	Published - May 1 2003

Keywords

HCV RNA
Hepatitis C
Total HCV core antigen

ASJC Scopus subject areas

Virology

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10.1002/jmv.10355

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title = "Total HCV core antigen assay: A new marker of hepatitis C viremia for monitoring the progress of therapy",

abstract = "The ability of the total hepatitis C virus (HCV) core antigen assay was evaluated for monitoring the therapeutic responses of HCV-infected patients treated with interferon. The ability to detect and quantitate an independent structural protein component of HCV, in the presence of circulating antibodies, makes this assay a valuable new tool in diagnosis and treatment monitoring. Measurement of total core antigen showed a strong dynamic correlation with HCV RNA data and may serve as an alternative direct marker of viral infection. In addition, with the advent of additional treatment protocols, a rapid, reliable assay for changes in HCV load may permit more frequent patient assessment and tailoring of the therapeutic regimen.",

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AU - Colombo, Massimo

AU - Bellati, Giorgio

AU - Tackney, Charles

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