Abstract
The ability of the total hepatitis C virus (HCV) core antigen assay was evaluated for monitoring the therapeutic responses of HCV-infected patients treated with interferon. The ability to detect and quantitate an independent structural protein component of HCV, in the presence of circulating antibodies, makes this assay a valuable new tool in diagnosis and treatment monitoring. Measurement of total core antigen showed a strong dynamic correlation with HCV RNA data and may serve as an alternative direct marker of viral infection. In addition, with the advent of additional treatment protocols, a rapid, reliable assay for changes in HCV load may permit more frequent patient assessment and tailoring of the therapeutic regimen.
| Original language | English |
|---|---|
| Pages (from-to) | 27-30 |
| Number of pages | 4 |
| Journal | Journal of Medical Virology |
| Volume | 70 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - May 1 2003 |
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Keywords
- HCV RNA
- Hepatitis C
- Total HCV core antigen
ASJC Scopus subject areas
- Virology
Cite this
Total HCV core antigen assay : A new marker of hepatitis C viremia for monitoring the progress of therapy. / Zanetti, Alessandro R.; Romanò, Luisa; Brunetto, Maurizia; Colombo, Massimo; Bellati, Giorgio; Tackney, Charles.
In: Journal of Medical Virology, Vol. 70, No. 1, 01.05.2003, p. 27-30.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Total HCV core antigen assay
T2 - A new marker of hepatitis C viremia for monitoring the progress of therapy
AU - Zanetti, Alessandro R.
AU - Romanò, Luisa
AU - Brunetto, Maurizia
AU - Colombo, Massimo
AU - Bellati, Giorgio
AU - Tackney, Charles
PY - 2003/5/1
Y1 - 2003/5/1
N2 - The ability of the total hepatitis C virus (HCV) core antigen assay was evaluated for monitoring the therapeutic responses of HCV-infected patients treated with interferon. The ability to detect and quantitate an independent structural protein component of HCV, in the presence of circulating antibodies, makes this assay a valuable new tool in diagnosis and treatment monitoring. Measurement of total core antigen showed a strong dynamic correlation with HCV RNA data and may serve as an alternative direct marker of viral infection. In addition, with the advent of additional treatment protocols, a rapid, reliable assay for changes in HCV load may permit more frequent patient assessment and tailoring of the therapeutic regimen.
AB - The ability of the total hepatitis C virus (HCV) core antigen assay was evaluated for monitoring the therapeutic responses of HCV-infected patients treated with interferon. The ability to detect and quantitate an independent structural protein component of HCV, in the presence of circulating antibodies, makes this assay a valuable new tool in diagnosis and treatment monitoring. Measurement of total core antigen showed a strong dynamic correlation with HCV RNA data and may serve as an alternative direct marker of viral infection. In addition, with the advent of additional treatment protocols, a rapid, reliable assay for changes in HCV load may permit more frequent patient assessment and tailoring of the therapeutic regimen.
KW - HCV RNA
KW - Hepatitis C
KW - Total HCV core antigen
UR - http://www.scopus.com/inward/record.url?scp=0037401622&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037401622&partnerID=8YFLogxK
U2 - 10.1002/jmv.10355
DO - 10.1002/jmv.10355
M3 - Article
C2 - 12629640
AN - SCOPUS:0037401622
VL - 70
SP - 27
EP - 30
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 0146-6615
IS - 1
ER -