Total Laparoscopic Hysterectomy in Early-Stage Endometrial Cancer Using an Intrauterine Manipulator

Is It a Bias for Frozen Section Analysis? Case-Control Study

F. Fanfani, M. L. Gagliardi, G. F. Zannoni, V. Gallotta, G. Vizzielli, A. Lecca, G. Scambia, A. Fagotti

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Study Objective: To evaluate whether the systematic use of an intrauterine manipulator influences the accuracy of frozen section analysis in early-stage endometrial cancer. Design: Case-control study (Canadian Task Force classification II-1). Patients: Three hundred fourteen consecutive women with early-stage endometrial cancer. Interventions: Between January 2004 and December 2009, 314 women with early-stage endometrial cancer underwent staging at laparoscopy (case group) or laparotomy (control group). All women in the case group underwent total laparoscopic hysterectomy using an intrauterine manipulator. Measurements and Main Results: The positive predictive value of frozen section analysis for myometrial infiltration, histotype, and grade of differentiation was 97.2%, 100%, and 97.2%, respectively. The correct diagnosis rate was of 85.7%. The accuracy of frozen section analysis, rate of correct diagnosis, and rate of tumor vascular invasion did not seem to be significantly modified by systematic use of an intrauterine manipulator for total laparoscopic hysterectomy compared with total abdominal hysterectomy in early-stage endometrial cancer staging. Conclusions: Frozen section analysis of early-stage endometrial cancer is highly accurate, and systematic use of an intrauterine manipulator does not represent a bias for correct evaluation of the specimen.

Original languageEnglish
Pages (from-to)184-188
Number of pages5
JournalJournal of Minimally Invasive Gynecology
Volume18
Issue number2
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Frozen Sections
Endometrial Neoplasms
Hysterectomy
Case-Control Studies
Neoplasm Staging
Advisory Committees
Laparoscopy
Laparotomy
Blood Vessels
Control Groups
Neoplasms

Keywords

  • Early endometrial cancer
  • Frozen section analysis
  • Intrauterine manipulator

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Total Laparoscopic Hysterectomy in Early-Stage Endometrial Cancer Using an Intrauterine Manipulator : Is It a Bias for Frozen Section Analysis? Case-Control Study. / Fanfani, F.; Gagliardi, M. L.; Zannoni, G. F.; Gallotta, V.; Vizzielli, G.; Lecca, A.; Scambia, G.; Fagotti, A.

In: Journal of Minimally Invasive Gynecology, Vol. 18, No. 2, 03.2011, p. 184-188.

Research output: Contribution to journalArticle

Fanfani, F. ; Gagliardi, M. L. ; Zannoni, G. F. ; Gallotta, V. ; Vizzielli, G. ; Lecca, A. ; Scambia, G. ; Fagotti, A. / Total Laparoscopic Hysterectomy in Early-Stage Endometrial Cancer Using an Intrauterine Manipulator : Is It a Bias for Frozen Section Analysis? Case-Control Study. In: Journal of Minimally Invasive Gynecology. 2011 ; Vol. 18, No. 2. pp. 184-188.
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abstract = "Study Objective: To evaluate whether the systematic use of an intrauterine manipulator influences the accuracy of frozen section analysis in early-stage endometrial cancer. Design: Case-control study (Canadian Task Force classification II-1). Patients: Three hundred fourteen consecutive women with early-stage endometrial cancer. Interventions: Between January 2004 and December 2009, 314 women with early-stage endometrial cancer underwent staging at laparoscopy (case group) or laparotomy (control group). All women in the case group underwent total laparoscopic hysterectomy using an intrauterine manipulator. Measurements and Main Results: The positive predictive value of frozen section analysis for myometrial infiltration, histotype, and grade of differentiation was 97.2{\%}, 100{\%}, and 97.2{\%}, respectively. The correct diagnosis rate was of 85.7{\%}. The accuracy of frozen section analysis, rate of correct diagnosis, and rate of tumor vascular invasion did not seem to be significantly modified by systematic use of an intrauterine manipulator for total laparoscopic hysterectomy compared with total abdominal hysterectomy in early-stage endometrial cancer staging. Conclusions: Frozen section analysis of early-stage endometrial cancer is highly accurate, and systematic use of an intrauterine manipulator does not represent a bias for correct evaluation of the specimen.",
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