Total Lesion Glycolysis and Sequential 90Y-Selective Internal Radiation Therapy in Breast Cancer Liver Metastases: Preliminary Results

Oreste Bagni, Luca Filippi, Giuseppe Pelle, Roberto Cianni, Orazio Schillaci

Research output: Contribution to journalArticlepeer-review


To assess the prognostic role of total lesion glycolysis (TLG) in patients with breast cancer liver metastases (BCLM) after sequential lobar 90Y-radioembolization (90Y-RE). Seventeen patients with bilobar BCLM underwent FDG PET/CT and TLG calculation before 90Y-RE. The hepatic lobe with the highest TLG was treated in the first session. PET was performed 6 weeks postprocedure and decrease in TLG (ΔTLG) in the treated lobe was calculated before the second 90Y administration. Subjects were divided in two groups (group 1: ΔTLG >50%, group 2: ΔTLG 90Y-therapies, patients underwent follow-up until death. Statistical analysis was performed to identify prognostic factors on overall survival (OS). After the first 90Y administration, 10 cases showed a ΔTLG >50% and seven had a ΔTLG value 50% and ΔTLG 90Y administration agrees with final outcome in BCLM patients after separate sequential lobar 90Y-RE.

Original languageEnglish
Pages (from-to)421-426
Number of pages6
JournalCancer Biotherapy and Radiopharmaceuticals
Issue number10
Publication statusPublished - Dec 1 2015


  • Y-radioembolization
  • breast cancer
  • Liver metastases
  • Total lesion glycolysis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology


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