Total sialic acid in patients with malignant melanoma

R. Valsecchi, A. Vernocchi, G. Tribbia, A. Di Landro, G. Imberti, T. Cainelli

Research output: Contribution to journalArticlepeer-review


Malignant cell surface glycoproteins and glycolipids have an altered carbohydrate composition that may contribute to aberrant intercellular recognition, cell adhesion, antigenicity and the invasiveness of malignant cells. These glycoproteins and glycolipids can be released into the sera. Since sialic acids are major constituents of glycoproteins and glycolipids, they are of considerable interest for their potential diagnostic and prognostic value. Sera of 59 healthy control subjects and 57 patients with malignant melanoma, 21 males and 36 females, aged 35-75 years, were studied by an enzymatic-colorimetric assay to determine total serum sialic acid levels. These were significantly higher in patients with malignant melanoma than in controls (p 3 mm.

Original languageEnglish
Pages (from-to)23-27
Number of pages5
JournalAnnali Italiani di Dermatologia Clinica e Sperimentale
Issue number1
Publication statusPublished - 1994


  • anatomic depth
  • disease stage
  • enzymatic-colorimetric-assay
  • malignant melanoma
  • total sialic acid

ASJC Scopus subject areas

  • Dermatology


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