Abstract
The first total synthesis of (±)-cyclooroidin, a member of the pyrrole-imidazole alkaloid family recently isolated from the sponge Agelas oroides in optically pure form, is described. The synthesis was achieved in nine linear steps, with an overall yield of 10%. Key step was a Wolff bromoketone synthesis performed on the intermediate longamide B.
Original language | English |
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Pages (from-to) | 8635-8638 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 46 |
Issue number | 50 |
DOIs | |
Publication status | Published - Dec 12 2005 |
Keywords
- Cyclooroidin
- Pyrrole-imidazole alkaloids
- Wolff bromoketone synthesis
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery