Touch or pain? Spatio-temporal patterns of cortical fMRI activity following brief mechanical stimuli

F. Lui, D. Duzzi, M. Corradini, M. Serafini, P. Baraldi, C. A. Porro

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Most imaging studies on the human pain system have concentrated so far on the spatial distribution of pain-related activity. In the present study, we investigated similarities and differences between the spatial and temporal patterns of brain activity related to touch vs. pain perception. To this end, we adopted an event-related functional magnetic resonance imaging (fMRI) paradigm allowing us to separately assess the activity related to stimulus anticipation, perception, and coding. The fMRI signal increases following brief mechanical noxious or non-noxious stimulation of the hand dorsum were largely overlapping in the contralateral and ipsilateral hemispheres, including portions of the parietal, insular, frontal and cingulate cortices. Higher activity following noxious stimulation was found in the contralateral mid-anterior insular cortex, in the anterior mid-cingulate cortex (aMCC) and in the adjacent dorso-medial frontal cortex. Significant decreases in fMRI signals following both tactile and painful stimuli were found in perigenual cingulate (pACC)/medial prefrontal cortex (MPF) and in the posterior cingulate/precuneus/paracentral lobule; more intense decreases were found in the pACC/MPF following painful stimuli. fMRI signal increases in the contralateral insula and in aMCC, but not in the parietal cortex, were more prolonged following painful than tactile stimuli. Moreover, a second peak of signal increases (albeit of lower intensity) was found in anterior insula and aMCC during pain intensity rating. These results show specific spatio-temporal patterns of cortical activity related to processing noxious vs. non-noxious mechanical stimuli.

Original languageEnglish
Pages (from-to)362-374
Number of pages13
JournalPain
Volume138
Issue number2
DOIs
Publication statusPublished - Aug 31 2008

Fingerprint

Gyrus Cinguli
Touch
Parietal Lobe
Magnetic Resonance Imaging
Pain
Frontal Lobe
Prefrontal Cortex
Cerebral Cortex
Pain Perception
Hand
Brain

Keywords

  • Cerebral cortex
  • Functional magnetic resonance imaging
  • Humans
  • pain
  • Touch

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Neuroscience(all)
  • Pharmacology
  • Clinical Psychology

Cite this

Lui, F., Duzzi, D., Corradini, M., Serafini, M., Baraldi, P., & Porro, C. A. (2008). Touch or pain? Spatio-temporal patterns of cortical fMRI activity following brief mechanical stimuli. Pain, 138(2), 362-374. https://doi.org/10.1016/j.pain.2008.01.010

Touch or pain? Spatio-temporal patterns of cortical fMRI activity following brief mechanical stimuli. / Lui, F.; Duzzi, D.; Corradini, M.; Serafini, M.; Baraldi, P.; Porro, C. A.

In: Pain, Vol. 138, No. 2, 31.08.2008, p. 362-374.

Research output: Contribution to journalArticle

Lui, F, Duzzi, D, Corradini, M, Serafini, M, Baraldi, P & Porro, CA 2008, 'Touch or pain? Spatio-temporal patterns of cortical fMRI activity following brief mechanical stimuli', Pain, vol. 138, no. 2, pp. 362-374. https://doi.org/10.1016/j.pain.2008.01.010
Lui, F. ; Duzzi, D. ; Corradini, M. ; Serafini, M. ; Baraldi, P. ; Porro, C. A. / Touch or pain? Spatio-temporal patterns of cortical fMRI activity following brief mechanical stimuli. In: Pain. 2008 ; Vol. 138, No. 2. pp. 362-374.
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