Tourette's syndrome and role of tetrabenazine: Review and personal experience

Mauro Porta, Marco Sassi, Mario Cavallazzi, Maurizio Fornari, Arianna Brambilla, Domenico Servello

Research output: Contribution to journalArticle

Abstract

Gilles de la Tourette's syndrome (Tourette's syndrome; TS) is an inherited tic disorder commonly associated with other neurobehavioural conditions such as attention-deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD). While the clinical presentation of TS and other features of this disorder have been well characterized, the genetic and neurobiological basis of the disease remains incompletely elucidated. The suggestion of a central role of dopamine in the aetiology of TS has been made on the basis of experimental studies, evidence from neuroimaging studies and the therapeutic response patients with TS have to agents that antagonize or interfere with putative dopaminergic pathways. Tetrabenazine is such an agent; it depletes presynaptic dopamine and serotonin stores and blocks postsynaptic dopamine receptors. In clinical studies, tetrabenazine has been found to be effective in a wide range of hyperkinetic movement disorders, including small numbers (

Original languageEnglish
Pages (from-to)443-459
Number of pages17
JournalClinical Drug Investigation
Volume28
Issue number7
DOIs
Publication statusPublished - 2008

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Keywords

  • Gilles de la Tourette's syndrome
  • Tetrabenazine, therapeutic use
  • Tic

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

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