Toward a more personalized motor function rehabilitation in Myotonic dystrophy type 1: The role of neuroplasticity

Simona Portaro, Antonino Naro, Antonino Chillura, Luana Billeri, Alessia Bramanti, Placido Bramanti, Carmelo Rodolico, Rocco Salvatore Calabrò

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Myotonic dystrophy type 1 (DM1) is the most prevalent adult muscular dystrophy, often accompanied by impairments in attention, memory, visuospatial and executive functions. Given that DM1 is a multi-system disorder, it requires a multi-disciplinary approach, including effective rehabilitation programs, focusing on the central nervous system neuroplasticity, in order to develop patient-tailored rehabilitative procedures for motor function recovery. Herein, we performed a transcranial magnetic stimulation (TMS) study aimed at investigating central motor conduction time, sensory-motor plasticity, and cortical excitability in 7 genetically defined DM1 patients. As compared to healthy individuals, DM1 patients showed a delayed central motor conduction time and an abnormal sensory-motor plasticity, with no alteration of cortical excitability. These findings may be useful to define patient-tailored motor rehabilitative programs.

Original languageEnglish
Article numbere0178470
JournalPLoS One
Volume12
Issue number5
DOIs
Publication statusPublished - 2017

Fingerprint

Myotonic Dystrophy
Neuronal Plasticity
Patient rehabilitation
Rehabilitation
Plasticity
Transcranial Magnetic Stimulation
Muscular Dystrophies
Executive Function
Recovery of Function
muscular dystrophy
Central Nervous System
Neurology
central nervous system
neuroplasticity
Data storage equipment
Recovery
Cortical Excitability

Keywords

  • Adolescent
  • Adult
  • Aged
  • Central Nervous System
  • Electromyography
  • Female
  • Humans
  • Male
  • Memory
  • Middle Aged
  • Myotonic Dystrophy
  • Neuritis
  • Neuronal Plasticity
  • Recovery of Function
  • Sensorimotor Cortex
  • Transcranial Magnetic Stimulation
  • Young Adult
  • Journal Article

Cite this

Toward a more personalized motor function rehabilitation in Myotonic dystrophy type 1: The role of neuroplasticity. / Portaro, Simona; Naro, Antonino; Chillura, Antonino; Billeri, Luana; Bramanti, Alessia; Bramanti, Placido; Rodolico, Carmelo; Calabrò, Rocco Salvatore.

In: PLoS One, Vol. 12, No. 5, e0178470, 2017.

Research output: Contribution to journalArticle

Portaro, Simona ; Naro, Antonino ; Chillura, Antonino ; Billeri, Luana ; Bramanti, Alessia ; Bramanti, Placido ; Rodolico, Carmelo ; Calabrò, Rocco Salvatore. / Toward a more personalized motor function rehabilitation in Myotonic dystrophy type 1: The role of neuroplasticity. In: PLoS One. 2017 ; Vol. 12, No. 5.
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