Toward a more personalized motor function rehabilitation in Myotonic dystrophy type 1: The role of neuroplasticity

Simona Portaro, Antonino Naro, Antonino Chillura, Luana Billeri, Alessia Bramanti, Placido Bramanti, Carmelo Rodolico, Rocco Salvatore Calabrò

Research output: Contribution to journalArticlepeer-review


Myotonic dystrophy type 1 (DM1) is the most prevalent adult muscular dystrophy, often accompanied by impairments in attention, memory, visuospatial and executive functions. Given that DM1 is a multi-system disorder, it requires a multi-disciplinary approach, including effective rehabilitation programs, focusing on the central nervous system neuroplasticity, in order to develop patient-tailored rehabilitative procedures for motor function recovery. Herein, we performed a transcranial magnetic stimulation (TMS) study aimed at investigating central motor conduction time, sensory-motor plasticity, and cortical excitability in 7 genetically defined DM1 patients. As compared to healthy individuals, DM1 patients showed a delayed central motor conduction time and an abnormal sensory-motor plasticity, with no alteration of cortical excitability. These findings may be useful to define patient-tailored motor rehabilitative programs.

Original languageEnglish
Article numbere0178470
JournalPLoS One
Issue number5
Publication statusPublished - 2017


  • Adolescent
  • Adult
  • Aged
  • Central Nervous System
  • Electromyography
  • Female
  • Humans
  • Male
  • Memory
  • Middle Aged
  • Myotonic Dystrophy
  • Neuritis
  • Neuronal Plasticity
  • Recovery of Function
  • Sensorimotor Cortex
  • Transcranial Magnetic Stimulation
  • Young Adult
  • Journal Article


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