Toward a personalized therapy in soft-tissue sarcomas: State of the art and future directions

Liliana Montella, Lucia Altucci, Federica Sarno, Carlo Buonerba, Stefano De Simone, Bianca Arianna Facchini, Elisena Franzese, Ferdinando De Vita, Salvatore Tafuto, Massimiliano Berretta, Gaetano Facchini

Research output: Contribution to journalReview articlepeer-review

Abstract

Soft-tissue sarcomas are rare tumors characterized by pathogenetic, morphological, and clinical intrinsic variability. Median survival of patients with advanced tumors are usually chemo-and radio-resistant, and standard treatments yield low response rates and poor survival results. The identification of defined genomic alterations in sarcoma could represent the premise for targeted treatments. Summarizing, soft-tissue sarcomas can be differentiated into histotypes with reciprocal chromosomal translocations, with defined oncogenic mutations and complex karyotypes. If the latter are improbably approached with targeted treatments, many suggest that innovative therapies interfering with the identified fusion oncoproteins and altered pathways could be potentially resolu-tive. In most cases, the characteristic genetic signature is discouragingly defined as “undruggable”, which poses a challenge for the development of novel pharmacological approaches. In this review, a summary of genomic alterations recognized in most common soft-tissue sarcoma is reported together with current and future therapeutic opportunities.

Original languageEnglish
Article number2359
JournalCancers
Volume13
Issue number10
DOIs
Publication statusPublished - May 2 2021

Keywords

  • Genome
  • Personalized medicine
  • Precision medicine
  • Sarcoma
  • Translocation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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