Toward a treat-to-target approach in the management of juvenile idiopathic arthritis

A. Consolaro, G. Negro, S. Lanni, N. Solari, A. Martini, A. Ravelli

Research output: Contribution to journalArticle

Abstract

Recent advances in the management of juvenile idiopathic arthritis (JIA) render disease remission an attainable goal in many, if not most, patients. This has led to suggestions that future treatment guidelines include an overriding goal to achieve clinical remission or, at least, minimal disease activity. Furthermore, implementation of treatment strategies aimed at achieving and maintaining tight disease control in standard paediatric rheumatology practice has been proposed. A compelling argument is available at this time to suggest that the incorporation of treat-totarget approach in the management of children with JIA may improve disease outcome. Recently, descriptions of disease states that represent suitable therapeutic targets, such as inactive disease, minimal disease activity, or parent- or child-acceptable symptom states, have been developed. In addition, criteria for these states based on the Juvenile Arthritis Disease Activity Score (JADAS) have been identified. Future studies will clarify whether the addition of an imaging assessment to the management of children with JIA will improve the prediction of clinical outcomes.

Original languageEnglish
JournalClinical and Experimental Rheumatology
Volume30
Issue number4 SUPPL.73
Publication statusPublished - 2012

Keywords

  • Acceptable symptom state
  • Inactive disease
  • Juvenile idiopathic arthritis
  • Minimal disease activity
  • Remission
  • Treat-to-target

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

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