Toward optimization of postremission therapy for residual disease-positive patients with acute myeloid leukemia

Luca Maurillo, Francesco Buccisano, Maria Ilaria Del Principe, Giovanni Del Poeta, Alessandra Spagnoli, Paola Panetta, Emanuele Ammatuna, Benedetta Neri, Licia Ottaviani, Chiara Sarlo, Daniela Venditti, Micol Quaresima, Raffaella Cerretti, Manuela Rizzo, Paolo De Fabritiis, Francesco L. Lo Coco, William Arcese, Sergio Amadori, Adriano Venditti

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Despite the identification of several baseline prognostic indicators, the outcome of patients with acute myeloid leukemia (AML) is generally heterogeneous. The effects of autologous (AuSCT) or allogeneic stem-cell transplantation (SCT) are still under evaluation. Minimal residual disease (MRD) states may be essential for assigning patients to therapy-dependent risk categories. Patients and Methods: By multiparametric flow cytometry, we assessed the levels of MRD in 142 patients with AML who achieved complete remission after intensive chemotherapy. Results: A level of 3.5 × 10-4 residual leukemia cells (RLCs) after consolidation therapy was established to identify MRD-negative and MRD-positive cases, with 5-year relapse-free survival (RFS) rates of 60% and 16%, respectively (P <.0001) and overall survival (OS) rates of 62% and 23%, respectively (P = .0001). Of patients (n = 77) who underwent a transplantation procedure (56 AuSCT and 21 SCT procedures); 42 patients (55%) were MRD positive (28 patients who underwent AuSCT and 14 patients who underwent SCT) and 35 patients (45%) were MRD negative (28 patients who underwent AuSCT and seven who underwent SCT). MRD-negative patients had a favorable prognosis, with only eight (22%) of 35 patients experiencing relapse, whereas 29 (69%) of 42 MRD-positive patients experienced relapse (P <.0001). In this high-risk group of 42 patients, we observed that 23 (82%) of 28 of those who underwent AuSCT experienced relapse, whereas six (43%) of 14 who underwent SCT experienced relapse (P = .014). Patients who underwent SCT also had a higher likelihood of RFS (47% v 14%). Conclusion: A threshold of 3.5 × 10-4 RLCs postconsolidation is critical for predicting disease outcome. MRD-negative patients have a good outcome regardless of the type of transplant they receive. In the MRD-positive group, AuSCT does not improve prognosis and SCT represents the primary option.

Original languageEnglish
Pages (from-to)4944-4951
Number of pages8
JournalJournal of Clinical Oncology
Volume26
Issue number30
DOIs
Publication statusPublished - Oct 20 2008

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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