Toward patient-specific simulations of cardiac valves: State-of-the-art and future directions

Emiliano Votta, Trung Bao Le, Marco Stevanella, Laura Fusini, Enrico G. Caiani, Alberto Redaelli, Fotis Sotiropoulos

Research output: Contribution to journalArticlepeer-review


Recent computational methods enabling patient-specific simulations of native and prosthetic heart valves are reviewed. Emphasis is placed on two critical components of such methods: (1) anatomically realistic finite element models for simulating the structural dynamics of heart valves; and (2) fluid structure interaction methods for simulating the performance of heart valves in a patient-specific beating left ventricle. It is shown that the significant progress achieved in both fronts paves the way toward clinically relevant computational models that can simulate the performance of a range of heart valves, native and prosthetic, in a patient-specific left heart environment. The significant algorithmic and model validation challenges that need to be tackled in the future to realize this goal are also discussed.

Original languageEnglish
Pages (from-to)217-228
Number of pages12
JournalJournal of Biomechanics
Issue number2
Publication statusPublished - Jan 18 2013


  • Finite element model
  • Fluid structure interaction
  • Heart valve
  • Medical imaging
  • Patient-specific modelling

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Rehabilitation
  • Biophysics
  • Biomedical Engineering


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