TY - JOUR
T1 - Toward precision medicine in primary biliary cholangitis
AU - Carbone, Marco
AU - Ronca, Vincenzo
AU - Bruno, Savino
AU - Invernizzi, Pietro
AU - Mells, George F.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Primary biliary cholangitis is a chronic, cholestatic liver disease characterized by a heterogeneous presentation, symptomatology, disease progression and response to therapy. In contrast, clinical management and treatment of PBC is homogeneous with a ‘one size fits all’ approach. The evolving research landscape, with the emergence of the -omics field and the availability of large patient cohorts are creating a unique opportunity of translational epidemiology. Furthermore, several novel disease and symptom-modifying agents for PBC are currently in development. The time is therefore ripe for precision medicine in PBC. In this manuscript we describe the concept of precision medicine; review current approaches to risk-stratification in PBC, and speculate how precision medicine in PBC might develop in the near future.
AB - Primary biliary cholangitis is a chronic, cholestatic liver disease characterized by a heterogeneous presentation, symptomatology, disease progression and response to therapy. In contrast, clinical management and treatment of PBC is homogeneous with a ‘one size fits all’ approach. The evolving research landscape, with the emergence of the -omics field and the availability of large patient cohorts are creating a unique opportunity of translational epidemiology. Furthermore, several novel disease and symptom-modifying agents for PBC are currently in development. The time is therefore ripe for precision medicine in PBC. In this manuscript we describe the concept of precision medicine; review current approaches to risk-stratification in PBC, and speculate how precision medicine in PBC might develop in the near future.
KW - Precision medicine
KW - Primary biliary cholangitis
KW - Risk-stratification
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U2 - 10.1016/j.dld.2016.05.023
DO - 10.1016/j.dld.2016.05.023
M3 - Review article
AN - SCOPUS:84990982220
VL - 48
SP - 843
EP - 850
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 8
ER -