Toward precision medicine in primary biliary cholangitis

Marco Carbone, Vincenzo Ronca, Savino Bruno, Pietro Invernizzi, George F. Mells

Research output: Contribution to journalReview articlepeer-review


Primary biliary cholangitis is a chronic, cholestatic liver disease characterized by a heterogeneous presentation, symptomatology, disease progression and response to therapy. In contrast, clinical management and treatment of PBC is homogeneous with a ‘one size fits all’ approach. The evolving research landscape, with the emergence of the -omics field and the availability of large patient cohorts are creating a unique opportunity of translational epidemiology. Furthermore, several novel disease and symptom-modifying agents for PBC are currently in development. The time is therefore ripe for precision medicine in PBC. In this manuscript we describe the concept of precision medicine; review current approaches to risk-stratification in PBC, and speculate how precision medicine in PBC might develop in the near future.

Original languageEnglish
Pages (from-to)843-850
Number of pages8
JournalDigestive and Liver Disease
Issue number8
Publication statusPublished - Aug 1 2016


  • Precision medicine
  • Primary biliary cholangitis
  • Risk-stratification

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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