Toward the definition of immunosuppressive regimens with antitumor activity

F. Casadio, S. Croci, A. D'Errico Grigioni, B. Corti, W. F. Grigioni, L. Landuzzi, P. L. Lollini

Research output: Contribution to journalArticle

Abstract

Immunosuppressive therapies associated with organ transplantation produce an increased risk of cancer development. Malignancies are increased in transplant recipients because of the impaired immune system. Moreover, experimental data point to a tumor-promoting activity of various immunosuppressive agents. In this study, we compared the effects of 4 immunosuppressive agents with different mechanisms of action (cyclosporine, rapamycin, mycophenolic acid, and leflunomide) on the in vitro growth of various tumor cell lines and umbilical vein endothelial cells. To varying degrees rapamycin (10 ng/mL), mycophenolic acid (300 nmol/L), and leflunomide (30 μmol/L) highly inhibited the growth of human rhabdomyosarcoma, hepatocellular carcinoma, colorectal carcinoma, and endothelial cells. In contrast, cyclosporine (100 ng/mL) did not affect their growth. Our data suggest that regimens containing rapamycin, mycophenolic acid, or leflunomide, which have both immunosuppressive and antitumor activities, should be preferred in transplant recipients to minimize the risk of tumors.

Original languageEnglish
Pages (from-to)2144-2147
Number of pages4
JournalTransplantation Proceedings
Volume37
Issue number5
DOIs
Publication statusPublished - Jun 2005

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leflunomide
Immunosuppressive Agents
Mycophenolic Acid
Sirolimus
Cyclosporine
Neoplasms
Endothelial Cells
Growth
Umbilical Veins
Rhabdomyosarcoma
Organ Transplantation
Tumor Cell Line
Hepatocellular Carcinoma
Colorectal Neoplasms
Immune System

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Casadio, F., Croci, S., D'Errico Grigioni, A., Corti, B., Grigioni, W. F., Landuzzi, L., & Lollini, P. L. (2005). Toward the definition of immunosuppressive regimens with antitumor activity. Transplantation Proceedings, 37(5), 2144-2147. https://doi.org/10.1016/j.transproceed.2005.03.089

Toward the definition of immunosuppressive regimens with antitumor activity. / Casadio, F.; Croci, S.; D'Errico Grigioni, A.; Corti, B.; Grigioni, W. F.; Landuzzi, L.; Lollini, P. L.

In: Transplantation Proceedings, Vol. 37, No. 5, 06.2005, p. 2144-2147.

Research output: Contribution to journalArticle

Casadio, F, Croci, S, D'Errico Grigioni, A, Corti, B, Grigioni, WF, Landuzzi, L & Lollini, PL 2005, 'Toward the definition of immunosuppressive regimens with antitumor activity', Transplantation Proceedings, vol. 37, no. 5, pp. 2144-2147. https://doi.org/10.1016/j.transproceed.2005.03.089
Casadio, F. ; Croci, S. ; D'Errico Grigioni, A. ; Corti, B. ; Grigioni, W. F. ; Landuzzi, L. ; Lollini, P. L. / Toward the definition of immunosuppressive regimens with antitumor activity. In: Transplantation Proceedings. 2005 ; Vol. 37, No. 5. pp. 2144-2147.
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