Toward understanding and exploiting tumor heterogeneity

Ash A. Alizadeh, Victoria Aranda, Alberto Bardelli, Cedric Blanpain, Christoph Bock, Christine Borowski, Carlos Caldas, Andrea Califano, Michael Doherty, Markus Elsner, Manel Esteller, Rebecca Fitzgerald, Jan O. Korbel, Peter Lichter, Christopher E. Mason, Nicholas Navin, Dana Pe'Er, Kornelia Polyak, Charles W M Roberts, Lillian SiuAlexandra Snyder, Hannah Stower, Charles Swanton, Roel G W Verhaak, Jean C. Zenklusen, Johannes Zuber, Jessica Zucman-Rossi

Research output: Contribution to journalArticle

Abstract

The extent of tumor heterogeneity is an emerging theme that researchers are only beginning to understand. How genetic and epigenetic heterogeneity affects tumor evolution and clinical progression is unknown. The precise nature of the environmental factors that influence this heterogeneity is also yet to be characterized. Nature Medicine, Nature Biotechnology and the Volkswagen Foundation organized a meeting focused on identifying the obstacles that need to be overcome to advance translational research in and tumor heterogeneity. Once these key questions were established, the attendees devised potential solutions. Their ideas are presented here.

Original languageEnglish
Pages (from-to)846-853
Number of pages8
JournalNature Medicine
Volume21
Issue number8
DOIs
Publication statusPublished - Aug 6 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Alizadeh, A. A., Aranda, V., Bardelli, A., Blanpain, C., Bock, C., Borowski, C., Caldas, C., Califano, A., Doherty, M., Elsner, M., Esteller, M., Fitzgerald, R., Korbel, J. O., Lichter, P., Mason, C. E., Navin, N., Pe'Er, D., Polyak, K., Roberts, C. W. M., ... Zucman-Rossi, J. (2015). Toward understanding and exploiting tumor heterogeneity. Nature Medicine, 21(8), 846-853. https://doi.org/10.1038/nm.3915