TY - JOUR
T1 - Towards a better understanding of the clinical association of anti-DFS70 autoantibodies
AU - Mahler, Michael
AU - Meroni, Pier Luigi
AU - Andrade, Luis E.
AU - Khamashta, Munther
AU - Bizzaro, Nicola
AU - Casiano, Carlos A.
AU - Fritzler, Marvin J.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Anti-DFS70 antibodies and their clinical associations remain an immunological paradox. Unlike other antinuclear antibodies (ANA), especially when present at high titres, anti-DFS70 antibodies are not prevalent in ANA associated rheumatic diseases. Despite significant interest and progress in understanding the clinical association of anti-DFS70 antibodies, no specific clinical associations have been confirmed. In reality, several studies reporting clinical association of these antibodies (i.e. atopic dermatitis, thrombosis, autoimmune thyroiditis) have added confusion instead of bringing significant insight. In addition, several groups have consistently reported on the occurrence of anti-DFS70 antibodies in a relevant fraction of apparently healthy individuals. This review aims to analyse the current knowledge and to provide future guidance to analyse potential clinical associations of anti-DFS70 antibodies by summarizing and interpreting recent findings.
AB - Anti-DFS70 antibodies and their clinical associations remain an immunological paradox. Unlike other antinuclear antibodies (ANA), especially when present at high titres, anti-DFS70 antibodies are not prevalent in ANA associated rheumatic diseases. Despite significant interest and progress in understanding the clinical association of anti-DFS70 antibodies, no specific clinical associations have been confirmed. In reality, several studies reporting clinical association of these antibodies (i.e. atopic dermatitis, thrombosis, autoimmune thyroiditis) have added confusion instead of bringing significant insight. In addition, several groups have consistently reported on the occurrence of anti-DFS70 antibodies in a relevant fraction of apparently healthy individuals. This review aims to analyse the current knowledge and to provide future guidance to analyse potential clinical associations of anti-DFS70 antibodies by summarizing and interpreting recent findings.
KW - Antinuclear antibodies
KW - Autoantibodies
KW - Autoimmune diseases
KW - DFS
KW - LEDGF
UR - http://www.scopus.com/inward/record.url?scp=84954365915&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84954365915&partnerID=8YFLogxK
U2 - 10.1016/j.autrev.2015.11.006
DO - 10.1016/j.autrev.2015.11.006
M3 - Article
C2 - 26588998
AN - SCOPUS:84954365915
VL - 15
SP - 198
EP - 201
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
SN - 1568-9972
IS - 2
ER -