Towards a better understanding of the clinical association of anti-DFS70 autoantibodies

Michael Mahler, Pier Luigi Meroni, Luis E. Andrade, Munther Khamashta, Nicola Bizzaro, Carlos A. Casiano, Marvin J. Fritzler

Research output: Contribution to journalArticle

Abstract

Anti-DFS70 antibodies and their clinical associations remain an immunological paradox. Unlike other antinuclear antibodies (ANA), especially when present at high titres, anti-DFS70 antibodies are not prevalent in ANA associated rheumatic diseases. Despite significant interest and progress in understanding the clinical association of anti-DFS70 antibodies, no specific clinical associations have been confirmed. In reality, several studies reporting clinical association of these antibodies (i.e. atopic dermatitis, thrombosis, autoimmune thyroiditis) have added confusion instead of bringing significant insight. In addition, several groups have consistently reported on the occurrence of anti-DFS70 antibodies in a relevant fraction of apparently healthy individuals. This review aims to analyse the current knowledge and to provide future guidance to analyse potential clinical associations of anti-DFS70 antibodies by summarizing and interpreting recent findings.

Original languageEnglish
Pages (from-to)198-201
Number of pages4
JournalAutoimmunity Reviews
Volume15
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

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Keywords

  • Antinuclear antibodies
  • Autoantibodies
  • Autoimmune diseases
  • DFS
  • LEDGF

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Mahler, M., Meroni, P. L., Andrade, L. E., Khamashta, M., Bizzaro, N., Casiano, C. A., & Fritzler, M. J. (2016). Towards a better understanding of the clinical association of anti-DFS70 autoantibodies. Autoimmunity Reviews, 15(2), 198-201. https://doi.org/10.1016/j.autrev.2015.11.006